GPX3 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O

Stable Identifier
Reaction [transition]
Homo sapiens
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Glutathione peroxidase 3 (GPX3) in plasma reduces hydrogen peroxide (H2O2) with glutathione to yield oxidized glutathione and water (Maddipati and Marnett 1987, Takahashi et al. 1987, Chung et al. 2009, Ottaviano et al. 2009). Glutathione is synthesized in the liver and exported into the plasma.

Literature References
PubMed ID Title Journal Year
3619451 Purification and characterization of human plasma glutathione peroxidase: a selenoglycoprotein distinct from the known cellular enzyme

Takahashi, K, Whitin, J, Cohen, H, Avissar, N

Arch. Biochem. Biophys. 1987
18936159 Glutathione peroxidase 3 mediates the antioxidant effect of peroxisome proliferator-activated receptor gamma in human skeletal muscle cells

Park, KS, Park, JW, Chung, SS, Lee, NS, Youn, BS, Kim, M, Lee, HK, Lee, IK, Cho, YM, Lee, YS, Kim, JB

Mol. Cell. Biol. 2009
19219623 Regulation of the extracellular antioxidant selenoprotein plasma glutathione peroxidase (GPx-3) in mammalian cells

Tang, SS, Handy, DE, Loscalzo, J, Ottaviano, FG

Mol. Cell. Biochem. 2009
3693360 Characterization of the major hydroperoxide-reducing activity of human plasma. Purification and properties of a selenium-dependent glutathione peroxidase

Maddipati, KR, Marnett, LJ

J. Biol. Chem. 1987
Catalyst Activity

glutathione peroxidase activity of GPX3 tetramer [extracellular region]

Orthologous Events
Cross References
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