Reactome | GPX3 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O

GPX3 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O

Stable Identifier

R-HSA-3341397

Type

Reaction [transition]

Species

Homo sapiens

Compartment

extracellular region

ReviewStatus

5/5

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GPX3 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O

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Glutathione peroxidase 3 (GPX3) in plasma reduces hydrogen peroxide (H2O2) with glutathione to yield oxidized glutathione and water (Maddipati and Marnett 1987, Takahashi et al. 1987, Chung et al. 2009, Ottaviano et al. 2009). Glutathione is synthesized in the liver and exported into the plasma.

Literature References

PubMed ID	Title	Journal	Year
3619451	Purification and characterization of human plasma glutathione peroxidase: a selenoglycoprotein distinct from the known cellular enzyme Takahashi, K, Avissar, N, Whitin, J, Cohen, H	Arch. Biochem. Biophys.	1987
18936159	Glutathione peroxidase 3 mediates the antioxidant effect of peroxisome proliferator-activated receptor gamma in human skeletal muscle cells Chung, SS, Kim, M, Youn, BS, Lee, NS, Park, JW, Lee, IK, Lee, YS, Kim, JB, Cho, YM, Lee, HK, Park, KS	Mol. Cell. Biol.	2009
19219623	Regulation of the extracellular antioxidant selenoprotein plasma glutathione peroxidase (GPx-3) in mammalian cells Ottaviano, FG, Tang, SS, Handy, DE, Loscalzo, J	Mol. Cell. Biochem.	2009
3693360	Characterization of the major hydroperoxide-reducing activity of human plasma. Purification and properties of a selenium-dependent glutathione peroxidase Maddipati, KR, Marnett, LJ	J. Biol. Chem.	1987