Reactome | GPX7,8 catalyze peroxidation of P4HB (PDI)

GPX7,8 catalyze peroxidation of P4HB (PDI)

Stable Identifier

R-HSA-3341296

Type

Reaction [transition]

Species

Homo sapiens

Compartment

endoplasmic reticulum lumen

ReviewStatus

5/5

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GPX7,8 catalyze peroxidation of P4HB (PDI)

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Glutathione peroxidase 7 (GPX7) and GPX8 are atypical glutathione peroxidases that catalyze the peroxidation of protein disulfide isomerases, such as PDI (P4HB) (Nguyen et al. 2011 and inferred from mouse in Bosello-Travain et al. 2013). GPX7 and GPX8 are each able to form heterodimers with the sulfhydryl oxidase ERO1alpha (ERO1L) in the endoplasmic reticulum lumen. It is hypothesized that GPX7 and GPX8 use hydrogen peroxide produced by ERO1L.

Literature References

PubMed ID	Title	Journal	Year
23454490	Protein disulfide isomerase and glutathione are alternative substrates in the one Cys catalytic cycle of glutathione peroxidase 7 Maiorino, M, Bosello-Travain, V, Negro, A, Ursini, F, Conrad, M, Quartesan, S, Toppo, S, Roveri, A, Rossetto, M, Cozza, G, Zaccarin, M	Biochim. Biophys. Acta	2013
21215271	Two endoplasmic reticulum PDI peroxidases increase the efficiency of the use of peroxide during disulfide bond formation Saaranen, MJ, Salo, KE, Raykhel, IB, Nguyen, VD, Karala, AR, Alanen, HI, Lappi, AK, Wang, L, Wang, CC, Ruddock, LW	J. Mol. Biol.	2011