Reactome | Superoxide reduces cytochrome c

Superoxide reduces cytochrome c

Stable Identifier

R-HSA-3341294

Type

Reaction [transition]

Species

Homo sapiens

Compartment

mitochondrial inner membrane, mitochondrial intermembrane space

ReviewStatus

5/5

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Superoxide can reduce cytochrome c in the intermembrane space (Wegerich et al. 2013, and inferred from other mammals in Butler et al. 1975, Koppenol et al. 1976, Butler et al. 1982). Superoxide has been shown in rat and mouse mitochondria to be released into the intermembrane space by the complex III of the respiratory chain (Han et al. 2001, Muller et al. 2004).

Literature References

PubMed ID	Title	Journal	Year
23455484	Mechanistic insights into the superoxide-cytochrome c reaction by lysine surface scanning Wegerich, F, Giachetti, A, Allegrozzi, M, Lisdat, F, Turano, P	J. Biol. Inorg. Chem.	2013
15317809	Complex III releases superoxide to both sides of the inner mitochondrial membrane Muller, FL, Liu, Y, Van Remmen, H	J. Biol. Chem.	2004
60	The reaction between the superoxide anion radical and cytochrome c Butler, J, Jayson, GG, Swallow, AJ	Biochim. Biophys. Acta	1975
6286671	Kinetics and mechanism of the reduction of ferricytochrome c by the superoxide anion Butler, J, Koppenol, WH, Margoliash, E	J. Biol. Chem.	1982
11139407	Mitochondrial respiratory chain-dependent generation of superoxide anion and its release into the intermembrane space Han, D, Williams, E, Cadenas, E	Biochem. J.	2001
10982	The kinetics of the reduction of cytochrome c by the superoxide anion radical Koppenol, WH, van Buuren, KJ, Butler, J, Braams, R	Biochim. Biophys. Acta	1976