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TAS2R43 [plasma membrane]
Stable Identifier
R-HSA-3299616
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Taste receptor type 2 member 43, T2R43_HUMAN
Locations in the PathwayBrowser
Expand all
Sensory Perception (Homo sapiens)
Sensory perception of taste (Homo sapiens)
Sensory perception of sweet, bitter, and umami (glutamate) taste (Homo sapiens)
Bitter compound binds bitter taste receptor (TAS2R) (Homo sapiens)
TAS2R:GNAT3:GDP:GNB1,3:GNG13 [plasma membrane] (Homo sapiens)
TAS2R (non-orphan) [plasma membrane] (Homo sapiens)
TAS2R43 [plasma membrane] (Homo sapiens)
TAS2R:ligand:GNAT3:GDP:GNB1,3:GNG13 [plasma membrane] (Homo sapiens)
TAS2R (non-orphan):ligand [plasma membrane] (Homo sapiens)
TAS2R43:ligand [plasma membrane] (Homo sapiens)
TAS2R43 [plasma membrane] (Homo sapiens)
GNAT3 exchanges GDP for GTP in TAS2R:bitter compound:GNAT3:GDP:GNB1,3:GNG13 (Homo sapiens)
TAS2R:ligand:GNAT3:GDP:GNB1,3:GNG13 [plasma membrane] (Homo sapiens)
TAS2R (non-orphan):ligand [plasma membrane] (Homo sapiens)
TAS2R43:ligand [plasma membrane] (Homo sapiens)
TAS2R43 [plasma membrane] (Homo sapiens)
TAS2R:ligand:GNAT3:GTP:GNB1,3:GNG13 [plasma membrane] (Homo sapiens)
TAS2R (non-orphan):ligand [plasma membrane] (Homo sapiens)
TAS2R43:ligand [plasma membrane] (Homo sapiens)
TAS2R43 [plasma membrane] (Homo sapiens)
TAS2R:bitter compound:GNAT3:GTP:GNB1,3:GNG13 dissociates yielding (Homo sapiens)
TAS2R (non-orphan):ligand [plasma membrane] (Homo sapiens)
TAS2R43:ligand [plasma membrane] (Homo sapiens)
TAS2R43 [plasma membrane] (Homo sapiens)
TAS2R:ligand:GNAT3:GTP:GNB1,3:GNG13 [plasma membrane] (Homo sapiens)
TAS2R (non-orphan):ligand [plasma membrane] (Homo sapiens)
TAS2R43:ligand [plasma membrane] (Homo sapiens)
TAS2R43 [plasma membrane] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (i) signalling events (Homo sapiens)
Liganded Gi-activating GPCR acts as a GEF for Gi (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
TAS2Rs:Bitter-tasting compounds [plasma membrane] (Homo sapiens)
TAS2Rs [plasma membrane] (Homo sapiens)
TAS2R43 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
TAS2Rs:Bitter-tasting compounds [plasma membrane] (Homo sapiens)
TAS2Rs [plasma membrane] (Homo sapiens)
TAS2R43 [plasma membrane] (Homo sapiens)
Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
TAS2Rs:Bitter-tasting compounds [plasma membrane] (Homo sapiens)
TAS2Rs [plasma membrane] (Homo sapiens)
TAS2R43 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
TAS2Rs:Bitter-tasting compounds [plasma membrane] (Homo sapiens)
TAS2Rs [plasma membrane] (Homo sapiens)
TAS2R43 [plasma membrane] (Homo sapiens)
The Ligand:GPCR:Gi complex dissociates (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
TAS2Rs:Bitter-tasting compounds [plasma membrane] (Homo sapiens)
TAS2Rs [plasma membrane] (Homo sapiens)
TAS2R43 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
TAS2Rs:Bitter-tasting compounds [plasma membrane] (Homo sapiens)
TAS2Rs [plasma membrane] (Homo sapiens)
TAS2R43 [plasma membrane] (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class C/3 (Metabotropic glutamate/pheromone receptors) (Homo sapiens)
T2Rs bind bitter-tasting compounds (Homo sapiens)
TAS2Rs [plasma membrane] (Homo sapiens)
TAS2R43 [plasma membrane] (Homo sapiens)
TAS2Rs:Bitter-tasting compounds [plasma membrane] (Homo sapiens)
TAS2Rs [plasma membrane] (Homo sapiens)
TAS2R43 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P59537 TAS2R43
Gene Names
TAS2R43
Chain
chain:1-309
Reference Genes
BioGPS Gene:259289 TAS2R43
COSMIC (genes):TAS2R43 TAS2R43
CTD Gene:259289 TAS2R43
dbSNP Gene:259289 TAS2R43
ENSEMBL:ENSG00000255374 TAS2R43
ENSEMBL:ENSG00000255374.3 TAS2R43
ENSEMBL:ENSG00000262612.3 TAS2R43
HGNC:18875 TAS2R43
KEGG Gene (Homo sapiens):259289 TAS2R43
Monarch:259289 TAS2R43
NCBI Gene:259289 TAS2R43
OMIM:612668 TAS2R43
UCSC:P59537 TAS2R43
Reference Transcript
RefSeq:NM_176884.2 TAS2R43
Other Identifiers
11738911_at
11738912_x_at
16761523
259289
259291
3444541
3444542
3444543
4053675
7961295
A_23_P371254
GE907075
GO:0001580
GO:0004930
GO:0005886
GO:0005929
GO:0007165
GO:0007186
GO:0008527
GO:0016020
GO:0023052
GO:0031514
GO:0033038
GO:0042995
GO:0043226
GO:0050877
GO:0050896
GO:0050909
GO:0060089
GO:0060170
HMNXSV003054831
ILMN_1730477
TC12001242.hg
Participates
as a component of
TAS2R43:ligand [plasma membrane] (Homo sapiens)
as a member of
TAS2R (non-orphan) [plasma membrane] (Homo sapiens)
TAS2Rs [plasma membrane] (Homo sapiens)
Inferred To
Tas2r120 [plasma membrane]
(Mus musculus)
Tas2r120 [plasma membrane]
(Rattus norvegicus)
t2r6 [plasma membrane]
(Xenopus tropicalis)
t2r37 [plasma membrane]
(Xenopus tropicalis)
CAFA-T2R43 [plasma membrane]
(Canis familiaris)
t2r24 [plasma membrane]
(Xenopus tropicalis)
Homologues of TAS2R20 [plasma membrane]
(Danio rerio)
Homologues of TAS2R20 [plasma membrane]
(Gallus gallus)
Homologues of TAS2R20 [plasma membrane]
(Xenopus tropicalis)
t2r49 [plasma membrane]
(Xenopus tropicalis)
t2r52 [plasma membrane]
(Xenopus tropicalis)
rab3gap2 [plasma membrane]
(Xenopus tropicalis)
t2r45 [plasma membrane]
(Xenopus tropicalis)
t2r5 [plasma membrane]
(Xenopus tropicalis)
LOC100492238 [plasma membrane]
(Xenopus tropicalis)
LOC101747503 [plasma membrane]
(Gallus gallus)
t2r50 [plasma membrane]
(Xenopus tropicalis)
LOC100486257 [plasma membrane]
(Xenopus tropicalis)
t2r38 [plasma membrane]
(Xenopus tropicalis)
t2r10 [plasma membrane]
(Xenopus tropicalis)
t2r20 [plasma membrane]
(Xenopus tropicalis)
t2r30 [plasma membrane]
(Xenopus tropicalis)
t2r36 [plasma membrane]
(Xenopus tropicalis)
LOC101731190 [plasma membrane]
(Xenopus tropicalis)
t2r4 [plasma membrane]
(Xenopus tropicalis)
t2r17 [plasma membrane]
(Xenopus tropicalis)
t2r41 [plasma membrane]
(Xenopus tropicalis)
LOC100492564 [plasma membrane]
(Xenopus tropicalis)
tas2r4 [plasma membrane]
(Xenopus tropicalis)
LOC782957 [plasma membrane]
(Bos taurus)
t2r34 [plasma membrane]
(Xenopus tropicalis)
LOC116407540 [plasma membrane]
(Xenopus tropicalis)
Tas2r136 [plasma membrane]
(Mus musculus)
Tas2r136 [plasma membrane]
(Rattus norvegicus)
t2r14 [plasma membrane]
(Xenopus tropicalis)
t2r9 [plasma membrane]
(Xenopus tropicalis)
t2r3 [plasma membrane]
(Xenopus tropicalis)
t2r19 [plasma membrane]
(Xenopus tropicalis)
TAS2R7 [plasma membrane]
(Gallus gallus)
TAS2R31 [plasma membrane]
(Bos taurus)
t2r42 [plasma membrane]
(Xenopus tropicalis)
t2r35 [plasma membrane]
(Xenopus tropicalis)
t2r8 [plasma membrane]
(Xenopus tropicalis)
t2r48 [plasma membrane]
(Xenopus tropicalis)
LOC100494566 [plasma membrane]
(Xenopus tropicalis)
t2r15 [plasma membrane]
(Xenopus tropicalis)
t2r22 [plasma membrane]
(Xenopus tropicalis)
TAS2R46 [plasma membrane]
(Bos taurus)
Homologues of TAS2R31 [plasma membrane]
(Bos taurus)
Homologues of TAS2R31 [plasma membrane]
(Canis familiaris)
Homologues of TAS2R31 [plasma membrane]
(Mus musculus)
Homologues of TAS2R31 [plasma membrane]
(Rattus norvegicus)
t2r2 [plasma membrane]
(Xenopus tropicalis)
TAS2R20 [plasma membrane]
(Canis familiaris)
TAS2R20 [plasma membrane]
(Danio rerio)
TAS2R20 [plasma membrane]
(Sus scrofa)
TAS2R20 [plasma membrane]
(Xenopus tropicalis)
tas2r39 [plasma membrane]
(Xenopus tropicalis)
LOC108648843 [plasma membrane]
(Xenopus tropicalis)
t2r53 [plasma membrane]
(Xenopus tropicalis)
t2r43 [plasma membrane]
(Xenopus tropicalis)
t2r13 [plasma membrane]
(Xenopus tropicalis)
TAS2R1a [plasma membrane]
(Danio rerio)
tas2r7 [plasma membrane]
(Xenopus tropicalis)
TAS2R40 [plasma membrane]
(Gallus gallus)
t2r54 [plasma membrane]
(Xenopus tropicalis)
Cross References
RefSeq
NP_795365.2
Guide to Pharmacology - Targets
678
OpenTargets
ENSG00000255374
GeneCards
P59537
HPA
ENSG00000255374-TAS2R43
Ensembl
ENST00000531678
,
ENSP00000458723
,
ENSG00000262612
,
ENSP00000431719
,
ENST00000571879
,
ENSG00000255374
PRO
P59537
Pharos - Targets
P59537
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