Reactome | TAS2R43 [plasma membrane]

TAS2R43 [plasma membrane]

Stable Identifier

R-HSA-3299616

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Taste receptor type 2 member 43, T2R43_HUMAN

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G alpha (i) signalling events (Homo sapiens)
      - Liganded Gi-activating GPCR acts as a GEF for Gi (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        TAS2Rs:Bitter-tasting compounds [plasma membrane] (Homo sapiens)
        
        TAS2Rs [plasma membrane] (Homo sapiens)
        
        TAS2R43 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        TAS2Rs:Bitter-tasting compounds [plasma membrane] (Homo sapiens)
        
        TAS2Rs [plasma membrane] (Homo sapiens)
        
        TAS2R43 [plasma membrane] (Homo sapiens)
      - Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        TAS2Rs:Bitter-tasting compounds [plasma membrane] (Homo sapiens)
        
        TAS2Rs [plasma membrane] (Homo sapiens)
        
        TAS2R43 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        TAS2Rs:Bitter-tasting compounds [plasma membrane] (Homo sapiens)
        
        TAS2Rs [plasma membrane] (Homo sapiens)
        
        TAS2R43 [plasma membrane] (Homo sapiens)
      - The Ligand:GPCR:Gi complex dissociates (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        TAS2Rs:Bitter-tasting compounds [plasma membrane] (Homo sapiens)
        
        TAS2Rs [plasma membrane] (Homo sapiens)
        
        TAS2R43 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        TAS2Rs:Bitter-tasting compounds [plasma membrane] (Homo sapiens)
        
        TAS2Rs [plasma membrane] (Homo sapiens)
        
        TAS2R43 [plasma membrane] (Homo sapiens)
  - GPCR ligand binding (Homo sapiens)
    - Class C/3 (Metabotropic glutamate/pheromone receptors) (Homo sapiens)
      - T2Rs bind bitter-tasting compounds (Homo sapiens)
        
        TAS2Rs [plasma membrane] (Homo sapiens)
        
        TAS2R43 [plasma membrane] (Homo sapiens)
        
        TAS2Rs:Bitter-tasting compounds [plasma membrane] (Homo sapiens)
        
        TAS2Rs [plasma membrane] (Homo sapiens)
        
        TAS2R43 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P59537 TAS2R43

Gene Names

TAS2R43

Chain

chain:1-309

Reference Genes

BioGPS Gene:259289 TAS2R43

COSMIC (genes):TAS2R43 TAS2R43

CTD Gene:259289 TAS2R43

dbSNP Gene:259289 TAS2R43

ENSEMBL:ENSG00000255374 TAS2R43

HGNC:18875 TAS2R43

KEGG:hsa:259289 TAS2R43

Monarch:259289 TAS2R43

NCBI Gene:259289 TAS2R43

OMIM:612668 TAS2R43

UCSC:P59537 TAS2R43

Reference Transcript

RefSeq:NM_176884.2 TAS2R43

Other Identifiers

11738911_at

11738912_x_at

16761523

259289

259291

3444541

3444542

3444543

4053675

7961295

A_23_P371254

GE907075

GO:0001580

GO:0004930

GO:0005886

GO:0005929

GO:0007186

GO:0008527

GO:0016020

GO:0031514

GO:0033038

GO:0043226

GO:0050877

GO:0050909

GO:0060089

GO:0060170

HMNXSV003054831

ILMN_1730477

TC12001242.hg

Participates

as a member of

as a component of

TAS2R43:ligand [plasma membrane] (Homo sapiens)

Inferred To

TAS2R46 [plasma membrane] (Bos taurus)

Tas2r120 [plasma membrane] (Mus musculus)

Tas2r120 [plasma membrane] (Rattus norvegicus)

Homologues of TAS2R31 [plasma membrane] (Bos taurus)

Homologues of TAS2R31 [plasma membrane] (Mus musculus)

Homologues of TAS2R31 [plasma membrane] (Rattus norvegicus)

Tas2r136 [plasma membrane] (Mus musculus)

Tas2r136 [plasma membrane] (Rattus norvegicus)

t2r14 [plasma membrane] (Xenopus tropicalis)

CAFA-T2R43 [plasma membrane] (Canis familiaris)

t2r2 [plasma membrane] (Xenopus tropicalis)

Homologues of TAS2R20 [plasma membrane] (Canis familiaris)

Homologues of TAS2R20 [plasma membrane] (Danio rerio)

Homologues of TAS2R20 [plasma membrane] (Gallus gallus)

Homologues of TAS2R20 [plasma membrane] (Xenopus tropicalis)

LOC100154902 [plasma membrane] (Sus scrofa)

t2r3 [plasma membrane] (Xenopus tropicalis)

TAS2R7 [plasma membrane] (Gallus gallus)

TAS2R31 [plasma membrane] (Bos taurus)

tas2r200.1 [plasma membrane] (Danio rerio)

tas2r7 [plasma membrane] (Xenopus tropicalis)

TAS2R40 [plasma membrane] (Gallus gallus)

LOC100682759 [plasma membrane] (Canis familiaris)

t2r15 [plasma membrane] (Xenopus tropicalis)

tas2r4 [plasma membrane] (Xenopus tropicalis)

LOC782957 [plasma membrane] (Bos taurus)

tas2r200.2 [plasma membrane] (Danio rerio)

LOC101747503 [plasma membrane] (Gallus gallus)

Cross References

RefSeq

NP_795365.2

Guide to Pharmacology - Targets

678

ENSEMBL

ENSP00000458723, ENSP00000431719, ENSG00000262612, ENSG00000255374, ENST00000531678, ENST00000571879

OpenTargets

ENSG00000255374

GeneCards

TAS2R43

HPA

ENSG00000255374-TAS2R43

PRO

P59537

Pharos - Targets

P59537

GlyGen

P59537