Most members of the TRP channel family are permeable to Ca2+. Although TRPM4 and 5 can be activated by increased levels of intracellular Ca2+, they are impermeable to it. Instead, they are monovalent-selective with highest affinity for Na+ transport, of which leads to depolarization of the membrane (Launay et al. 2002, Prawitt et al. 2003). They play a central role in cardiomyocytes, neurons, endocrine pancreas cells, kidney epithelial cells and cochlea hair cells.
Kinet, JP, Fleig, A, Perraud, AL, Penner, R, Launay, P, Scharenberg, AM
Fleig, A, Penner, R, Monteilh-Zoller, MK, Spangenberg, C, Zabel, B, Prawitt, D, Brixel, L
sodium channel activity of TRPM4,5 [plasma membrane]
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