Reactome | G6PC2 hydrolyzes G6P to form Glc and Pi (islet)

G6PC2 hydrolyzes G6P to form Glc and Pi (islet)

Stable Identifier

R-HSA-3266566

Type

Reaction [transition]

Species

Homo sapiens

Compartment

endoplasmic reticulum lumen, endoplasmic reticulum membrane

Synonyms

alpha-D-Glucose 6-phosphate + H2O => alpha-D-Glucose + Orthophosphate (G6PC2 - islet)

ReviewStatus

5/5

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G6PC2 hydrolyzes G6P to form Glc and Pi (islet)

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G6PC2 (Glucose-6-phosphatase 2), associated with the endoplasmic reticulum membrane catalyzes the hydrolysis of glucose-6-phosphate (G6P) to glucose (Glc) and orthophosphate (Pi). This reaction is essentially irreversible. This enzyme is expressed in islet cells of the pancreas (Petrolonis et al. 2004).

Literature References

PubMed ID	Title	Journal	Year
14722102	Enzymatic characterization of the pancreatic islet-specific glucose-6-phosphatase-related protein (IGRP) Jain, S, Prack, AE, An, WF, Fish, SM, Tartaglia, LA, Tummino, PJ, Ge, L, Schuller, AG, Langston, SP, Petrolonis, AJ, Yang, Q, Dales, NA, Hong, SB, Parsons, TF, Li, P, Chen, H	J Biol Chem	2004