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N4GlycoAsn-PalmS WNT1 [extracellular region]
Stable Identifier
R-HSA-3247804
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
N4GlycoAsn-O-palmitoleyl-L-serine-WNT1, palmitoleyl-N-glycosyl WNT1, palmitoyleol-N-glycosyl WNT1
Icon
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by WNT (Homo sapiens)
Beta-catenin independent WNT signaling (Homo sapiens)
PCP/CE pathway (Homo sapiens)
DVL is recruited to the receptor (Homo sapiens)
WNT:FZD [plasma membrane] (Homo sapiens)
PCP pathway WNTs [extracellular region] (Homo sapiens)
N4GlycoAsn-PalmS WNT1 [extracellular region] (Homo sapiens)
WNT:FZD:pDVL [plasma membrane] (Homo sapiens)
WNT:FZD [plasma membrane] (Homo sapiens)
PCP pathway WNTs [extracellular region] (Homo sapiens)
N4GlycoAsn-PalmS WNT1 [extracellular region] (Homo sapiens)
WNT-dependent phosphorylation of DVL (Homo sapiens)
WNT:FZD [plasma membrane] (Homo sapiens)
PCP pathway WNTs [extracellular region] (Homo sapiens)
N4GlycoAsn-PalmS WNT1 [extracellular region] (Homo sapiens)
WNT:FZD:pDVL [plasma membrane] (Homo sapiens)
WNT:FZD [plasma membrane] (Homo sapiens)
PCP pathway WNTs [extracellular region] (Homo sapiens)
N4GlycoAsn-PalmS WNT1 [extracellular region] (Homo sapiens)
WNTs bind the FZD receptor to initiate PCP pathway (Homo sapiens)
PCP pathway WNTs [extracellular region] (Homo sapiens)
N4GlycoAsn-PalmS WNT1 [extracellular region] (Homo sapiens)
WNT:FZD [plasma membrane] (Homo sapiens)
PCP pathway WNTs [extracellular region] (Homo sapiens)
N4GlycoAsn-PalmS WNT1 [extracellular region] (Homo sapiens)
TCF dependent signaling in response to WNT (Homo sapiens)
Canonical WNT signaling through the atypical receptor RYK (Homo sapiens)
RYK-binding WNTs [extracellular region] (Homo sapiens)
N4GlycoAsn-PalmS WNT1 [extracellular region] (Homo sapiens)
RYK:WNTs [plasma membrane] (Homo sapiens)
RYK-binding WNTs [extracellular region] (Homo sapiens)
N4GlycoAsn-PalmS WNT1 [extracellular region] (Homo sapiens)
Disassembly of the destruction complex and recruitment of AXIN to the membrane (Homo sapiens)
Beta-catenin is released from the destruction complex (Homo sapiens)
WNT:FZD:LRP5/6:DVL [plasma membrane] (Homo sapiens)
WNT:FZD:LRP5/6 [plasma membrane] (Homo sapiens)
canonical WNTs [extracellular region] (Homo sapiens)
N4GlycoAsn-PalmS WNT1 [extracellular region] (Homo sapiens)
WNT:FZD:p10S/T-LRP5/6:DVL:AXIN:GSK3B [plasma membrane] (Homo sapiens)
canonical WNTs [extracellular region] (Homo sapiens)
N4GlycoAsn-PalmS WNT1 [extracellular region] (Homo sapiens)
DVL recruits GSK3beta:AXIN1 to the receptor complex (Homo sapiens)
WNT:FZD:LRP5/6:DVL [plasma membrane] (Homo sapiens)
WNT:FZD:LRP5/6 [plasma membrane] (Homo sapiens)
canonical WNTs [extracellular region] (Homo sapiens)
N4GlycoAsn-PalmS WNT1 [extracellular region] (Homo sapiens)
WNT:FZD:LRP5/6:DVL:AXIN:GSK3B [plasma membrane] (Homo sapiens)
WNT:FZD:LRP5/6:DVL [plasma membrane] (Homo sapiens)
WNT:FZD:LRP5/6 [plasma membrane] (Homo sapiens)
canonical WNTs [extracellular region] (Homo sapiens)
N4GlycoAsn-PalmS WNT1 [extracellular region] (Homo sapiens)
Phosphorylation of LRP5/6 cytoplasmic domain by CSNKI (Homo sapiens)
WNT:FZD:p10S/T-LRP5/6:DVL:AXIN:GSK3B [plasma membrane] (Homo sapiens)
canonical WNTs [extracellular region] (Homo sapiens)
N4GlycoAsn-PalmS WNT1 [extracellular region] (Homo sapiens)
WNT:FZD:p5S/T-LRP5/6:DVL:AXIN:GSK3B [plasma membrane] (Homo sapiens)
canonical WNTs [extracellular region] (Homo sapiens)
N4GlycoAsn-PalmS WNT1 [extracellular region] (Homo sapiens)
Phosphorylation of LRP5/6 cytoplasmic domain by membrane-associated GSK3beta (Homo sapiens)
WNT:FZD:LRP5/6:DVL:AXIN:GSK3B [plasma membrane] (Homo sapiens)
WNT:FZD:LRP5/6:DVL [plasma membrane] (Homo sapiens)
WNT:FZD:LRP5/6 [plasma membrane] (Homo sapiens)
canonical WNTs [extracellular region] (Homo sapiens)
N4GlycoAsn-PalmS WNT1 [extracellular region] (Homo sapiens)
WNT:FZD:p5S/T-LRP5/6:DVL:AXIN:GSK3B [plasma membrane] (Homo sapiens)
canonical WNTs [extracellular region] (Homo sapiens)
N4GlycoAsn-PalmS WNT1 [extracellular region] (Homo sapiens)
FZD recruits DVL to the receptor complex (Homo sapiens)
WNT:FZD:LRP5/6 [plasma membrane] (Homo sapiens)
canonical WNTs [extracellular region] (Homo sapiens)
N4GlycoAsn-PalmS WNT1 [extracellular region] (Homo sapiens)
WNT:FZD:LRP5/6:DVL [plasma membrane] (Homo sapiens)
WNT:FZD:LRP5/6 [plasma membrane] (Homo sapiens)
canonical WNTs [extracellular region] (Homo sapiens)
N4GlycoAsn-PalmS WNT1 [extracellular region] (Homo sapiens)
WNT binds to FZD and LRP5/6 (Homo sapiens)
WNT:FZD:LRP5/6 [plasma membrane] (Homo sapiens)
canonical WNTs [extracellular region] (Homo sapiens)
N4GlycoAsn-PalmS WNT1 [extracellular region] (Homo sapiens)
canonical WNTs [extracellular region] (Homo sapiens)
N4GlycoAsn-PalmS WNT1 [extracellular region] (Homo sapiens)
WNT ligand biogenesis and trafficking (Homo sapiens)
secretion of WNT ligands (Homo sapiens)
WNTs [extracellular region] (Homo sapiens)
N4GlycoAsn-PalmS WNT1 [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:P04628 WNT1
Gene Names
WNT1, INT1
Chain
signal peptide:1-27, chain:28-370
Reference Genes
BioGPS Gene:7471 WNT1
COSMIC (genes):WNT1 WNT1
CTD Gene:7471 WNT1
dbSNP Gene:7471 WNT1
ENSEMBL:ENSG00000125084 WNT1
HGNC:12774 WNT1
KEGG:hsa:7471 WNT1
Monarch:7471 WNT1
NCBI Gene:7471 WNT1
OMIM:164820 WNT1
UCSC:P04628 WNT1
Reference Transcript
RefSeq:NM_005430.3 WNT1
Other Identifiers
11738535_at
11738536_at
16750690
1853_at
208570_PM_at
208570_at
3413702
3413703
3413704
3413707
3413711
3413712
3413713
3413715
3413716
7471
7955170
A_23_P411157
A_33_P3382588
GE63384
GO:0000578
GO:0001658
GO:0002376
GO:0005102
GO:0005109
GO:0005125
GO:0005576
GO:0005615
GO:0005737
GO:0005788
GO:0005796
GO:0005886
GO:0006355
GO:0007267
GO:0007275
GO:0007520
GO:0008283
GO:0008284
GO:0009611
GO:0009986
GO:0010592
GO:0010812
GO:0014902
GO:0016015
GO:0016055
GO:0019904
GO:0021527
GO:0021536
GO:0021549
GO:0021551
GO:0021588
GO:0021797
GO:0022004
GO:0022008
GO:0022037
GO:0022408
GO:0023052
GO:0030154
GO:0030182
GO:0030512
GO:0030514
GO:0030666
GO:0030901
GO:0030917
GO:0031100
GO:0033077
GO:0033278
GO:0036520
GO:0042472
GO:0042770
GO:0043066
GO:0043226
GO:0043568
GO:0045165
GO:0045444
GO:0045596
GO:0045599
GO:0045747
GO:0045893
GO:0045944
GO:0048018
GO:0048146
GO:0048663
GO:0048664
GO:0048856
GO:0051091
GO:0060061
GO:0060070
GO:0060348
GO:0061184
GO:0070062
GO:0070365
GO:0071375
GO:0071425
GO:0071542
GO:0098772
GO:1902035
GO:1903377
GO:1904948
GO:1990403
GO:2000059
GO:2000773
HMNXSV003000642
ILMN_1814443
PH_hs_0013172
TC12000360.hg
X03072_at
g4885654_3p_at
Participates
as a member of
RYK-binding WNTs [extracellular region] (Homo sapiens)
canonical WNTs [extracellular region] (Homo sapiens)
PCP pathway WNTs [extracellular region] (Homo sapiens)
WNTs [extracellular region] (Homo sapiens)
Other forms of this molecule
WNT1 [extracellular region]
N4GlycoAsn-PalmS WNT1 [extracellular exosome]
N4GlycoAsn-PalmS WNT1 [endocytic vesicle membrane]
WNT1 [endoplasmic reticulum lumen]
N4GlycoAsn-WNT1 [endoplasmic reticulum lumen]
N4GlycoAsn-PalmS WNT1 [endoplasmic reticulum lumen]
N4GlycoAsn-PalmS WNT1 [Golgi lumen]
N4GlycoAsn-PalmS WNT1 [plasma membrane]
Inferred To
Wnt1 [extracellular region]
(Mus musculus)
Wnt1 [extracellular region]
(Rattus norvegicus)
wnt1 [extracellular region]
(Danio rerio)
wnt1 [extracellular region]
(Xenopus tropicalis)
wg [extracellular region]
(Drosophila melanogaster)
N4GlycoAsn-PalmS WNT1 [extracellular region]
(Gallus gallus)
WNT1 [extracellular region]
(Bos taurus)
WNT1 [extracellular region]
(Canis familiaris)
WNT1 [extracellular region]
(Sus scrofa)
Modified Residues
Name
N4-glycosyl-L-asparagine at unknown position
PsiMod Name
N4-glycosyl-L-asparagine
PsiMod Definition
A protein modification that effectively converts an L-asparagine residue to an N4-glycosyl-L-asparagine.
Name
O-palmitoleyl-L-serine at 224
Coordinate
224
PsiMod Name
O-palmitoleyl-L-serine
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-palmitoleyl-L-serine.
Cross References
RefSeq
NP_005421.1
ENSEMBL
ENSP00000293549
,
ENST00000293549
OpenTargets
ENSG00000125084
HPA
ENSG00000125084-WNT1
PRO
P04628
Pharos - Targets
P04628
GlyGen
P04628
Orphanet
WNT1
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