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E2F1/2/3:DP1/2 binds EED gene promoter
Stable Identifier
R-HSA-3240765
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
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Cellular Senescence (Homo sapiens)
Oxidative Stress Induced Senescence (Homo sapiens)
E2F1/2/3:DP1/2 binds EED gene promoter (Homo sapiens)
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EED gene contains several E2F binding sites in its promoter, and these E2F-binding sites are needed for the responsiveness of EED promoter to E2F1, E2F2 and E2F3. Only E2F1 with intact DNA-binding domain stimulates EED transcription. Binding of E2F3 to EED promoter was directly demonstrated by ChIP (Bracken et al. 2003).
Literature References
PubMed ID
Title
Journal
Year
14532106
EZH2 is downstream of the pRB-E2F pathway, essential for proliferation and amplified in cancer
Helin, K
,
Bracken, AP
,
Prosperini, E
,
Capra, M
,
Colli, E
,
Pasini, D
EMBO J.
2003
Participants
Input
E2F1,E2F2,E2F3:TFDP1,TFDP2 [nucleoplasm]
(Homo sapiens)
EED Gene [nucleoplasm]
(Homo sapiens)
Output
EED Gene:E2F1/2/3:DP1/2 [nucleoplasm]
(Homo sapiens)
Participates
as an event of
Oxidative Stress Induced Senescence (Homo sapiens)
Authored
Orlic-Milacic, M (2013-07-15)
Reviewed
Samarajiwa, S (2013-09-03)
Created
Orlic-Milacic, M (2013-03-28)
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