E2F1/2/3:DP1/2 binds EED gene promoter

Stable Identifier
R-HSA-3240765
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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EED gene contains several E2F binding sites in its promoter, and these E2F-binding sites are needed for the responsiveness of EED promoter to E2F1, E2F2 and E2F3. Only E2F1 with intact DNA-binding domain stimulates EED transcription. Binding of E2F3 to EED promoter was directly demonstrated by ChIP (Bracken et al. 2003).

Literature References
PubMed ID Title Journal Year
14532106 EZH2 is downstream of the pRB-E2F pathway, essential for proliferation and amplified in cancer

Bracken, AP, Pasini, D, Capra, M, Prosperini, E, Colli, E, Helin, K

EMBO J. 2003
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