Expression of MINK1/TNIK is positively regulated by ROS

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R-HSA-3225867
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Reaction [omitted]
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Homo sapiens
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Reactive oxygen species (ROS) generated as a consequence of oncogenic RAS signaling induce expression and activation of Ste20 family kinases MINK1 (MINK), TNIK and, possibly, MAP4K4, which contributes to growth arrest and cellular senescence (Nicke et al. 2005).

Literature References
PubMed ID Title Journal Year
16337592 Involvement of MINK, a Ste20 family kinase, in Ras oncogene-induced growth arrest in human ovarian surface epithelial cells

Nicke, B, Bastien, J, Khanna, SJ, Warne, PH, Cowling, V, Cook, SJ, Peters, G, Delpuech, O, Schulze, A, Berns, K, Mullenders, J, Beijersbergen, RL, Bernards, R, Ganesan, TS, Downward, J, Hancock, DC

Mol. Cell 2005
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