Reactome | L3MBTL1 binds TP53 monomethylated on K382

L3MBTL1 binds TP53 monomethylated on K382

Stable Identifier

R-HSA-3222116

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

Locations in the PathwayBrowser

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Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - Regulation of TP53 Activity (Homo sapiens)
        
        Regulation of TP53 Activity through Methylation (Homo sapiens)
        
        L3MBTL1 binds TP53 monomethylated on K382 (Homo sapiens)

General

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L3MBTL1 binds TP53 monomethylated on K382

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The chromatin compaction factor L3MBTL1 binds TP53 (p53) monomethylated at lysine K382 by lysine methyltransferase SETD8 (SET8). L3MBTL1 binding to TP53 leads to chromatin reorganization at TP53-bound promoters, resulting in repression of gene transcription (West et al. 2010).

Literature References

PubMed ID	Title	Journal	Year
20870725	The MBT repeats of L3MBTL1 link SET8-mediated p53 methylation at lysine 382 to target gene repression West, LE, Roy, S, Lachmi-Weiner, K, Hayashi, R, Shi, X, Appella, E, Kutateladze, TG, Gozani, O	J. Biol. Chem.	2010