Reactome | L3MBTL1 binds TP53 monomethylated on K382

L3MBTL1 binds TP53 monomethylated on K382

Stable Identifier

R-HSA-3222116

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - Regulation of TP53 Activity (Homo sapiens)
        
        Regulation of TP53 Activity through Methylation (Homo sapiens)
        
        L3MBTL1 binds TP53 monomethylated on K382 (Homo sapiens)

General

SBML | | PDF

SVG | | PPTX | SBGN

L3MBTL1 binds TP53 monomethylated on K382

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The chromatin compaction factor L3MBTL1 binds TP53 (p53) monomethylated at lysine K382 by lysine methyltransferase SETD8 (SET8). L3MBTL1 binding to TP53 leads to chromatin reorganization at TP53-bound promoters, resulting in repression of gene transcription (West et al. 2010).

Literature References

PubMed ID	Title	Journal	Year
20870725	The MBT repeats of L3MBTL1 link SET8-mediated p53 methylation at lysine 382 to target gene repression Hayashi, R, Kutateladze, TG, Roy, S, Appella, E, Lachmi-Weiner, K, Gozani, O, Shi, X, West, LE	J. Biol. Chem.	2010