AOX1 oxidises PXL to PDXate

Stable Identifier
R-HSA-3204311
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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AOX1 oxidises PXL to PDXate
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Aldehyde oxidase (AOX1) is a complex molybdo-flavoprotein that belongs to the xanthine oxidase family. It is active as a homodimer, with each monomer binding two distinct [2Fe2S] clusters, FAD and the molybdenum cofactor. AOX1 plays an important role in the metabolism of drugs based on its broad substrate specificity oxidising aromatic aza-heterocycles and aldehydes (Hartmann et al. 2012).
Literature References
PubMed ID Title Journal Year
22279051 The impact of single nucleotide polymorphisms on human aldehyde oxidase

Leimkühler, S, Jones, JP, Alfaro, JF, Hartmann, T, Terao, M, Garattini, E, Teutloff, C

Drug Metab. Dispos. 2012
Participants
Input
Output
Participates
as an event of
Catalyst Activity

aldehyde oxidase activity of 2xAOX1:cofactors [cytosol]

Physical Entity
2xAOX1:cofactors [cytosol] (Homo sapiens)
Activity
aldehyde oxidase activity (GO:0004031)
Orthologous Events
AOX1 oxidises PXL to PDXate (Bos taurus)
AOX1 oxidises PXL to PDXate (Caenorhabditis elegans)
AOX1 oxidises PXL to PDXate (Danio rerio)
AOX1 oxidises PXL to PDXate (Dictyostelium discoideum)
AOX1 oxidises PXL to PDXate (Drosophila melanogaster)
AOX1 oxidises PXL to PDXate (Gallus gallus)
AOX1 oxidises PXL to PDXate (Mus musculus)
AOX1 oxidises PXL to PDXate (Rattus norvegicus)
AOX1 oxidises PXL to PDXate (Sus scrofa)
AOX1 oxidises PXL to PDXate (Xenopus tropicalis)
Cross References
Rhea
Authored
Jassal, B  (2013-03-01)
Reviewed
D'Eustachio, P  (2013-04-15)
Created
Jassal, B  (2013-03-01)
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