AOX1 oxidises PXL to PDXate

Stable Identifier
R-HSA-3204311
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Aldehyde oxidase (AOX1) is a complex molybdo-flavoprotein that belongs to the xanthine oxidase family. It is active as a homodimer, with each monomer binding two distinct [2Fe2S] clusters, FAD and the molybdenum cofactor. AOX1 plays an important role in the metabolism of drugs based on its broad substrate specificity oxidising aromatic aza-heterocycles and aldehydes (Hartmann et al. 2012).

Literature References
PubMed ID Title Journal Year
22279051 The impact of single nucleotide polymorphisms on human aldehyde oxidase

Hartmann, T, Terao, M, Garattini, E, Teutloff, C, Alfaro, JF, Jones, JP, Leimk├╝hler, S

Drug Metab. Dispos. 2012
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
aldehyde oxidase activity of 2xAOX1:cofactors [cytosol]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created
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