Reactome | NR1H4-3 [nucleoplasm]

NR1H4-3 [nucleoplasm]

Stable Identifier

R-HSA-3196171

Type

Genes and Transcripts [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Bile acid receptor isoform 3

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q96RI1-3 NR1H4

Gene Names

NR1H4, BAR, FXR, HRR1, RIP14

Participates

as a candidate of

NR [nucleoplasm] (Homo sapiens)

Inferred To

nr1h4 [nucleoplasm] (Danio rerio)

nr1h4 [nucleoplasm] (Xenopus tropicalis)

FXR [nucleoplasm] (Gallus gallus)

EcR [nucleoplasm] (Drosophila melanogaster)

NR1H4 [nucleoplasm] (Bos taurus)

NR1H4 [nucleoplasm] (Canis familiaris)

NR1H4 [nucleoplasm] (Mus musculus)

NR1H4 [nucleoplasm] (Rattus norvegicus)

NR1H4 [nucleoplasm] (Sus scrofa)

Cross References

Guide to Pharmacology - Targets

603

OpenTargets

ENSG00000012504

ENSEMBL

ENSP00000376712, ENST00000648861, ENST00000188403, ENST00000392986, ENSG00000012504, ENSP00000448506, ENST00000551379, ENST00000549996, ENSP00000448978, ENSP00000447149, ENSP00000496908, ENST00000548884, ENSP00000188403

ZINC - FDA approved

NR1H4_HUMAN

ZINC - Substances

NR1H4_HUMAN

ZINC - Biogenic

NR1H4_HUMAN

ZINC target

Q96RI1

PRO

Q96RI1

PDB

5Q19, 3OKI, 3OLF, 3RVF, 5Y49, 6A5Z, 5Y44, 5Q0L, 5Q0M, 5Q0P, 5Q1G, 5Q1A, 5Q0W, 3FXV, 5Q0Q, 5Q0V, 7TRB, 5Y1J, 5Q10, 3DCU, 5Q0Y, 6HL1, 5Q0R, 5Q14, 5Q0K, 5YXB, 3RUT, 5YXL, 3BEJ, 7VUE, 6A5X, 3HC6, 3P89, 6HL0, 4WVD, 3OMM, 3OMK, 5Q16, 5IAW, 5Q1E, 5Q15, 4QE8, 3DCT, 8HD3, 5Q0Z, 6A60, 3OKH, 3OOK, 7D42, 6A5W, 5Q1H, 5Q1B, 5Q12, 5YXD, 3OOF, 5Z12, 5Q18, 3FLI, 5Q17, 5Q1I, 5Q1D, 5Q1C, 5Q0N, 5Q0O, 5Q0X, 8HBM, 5YXJ, 3RUU, 5Q0J, 5Q0S, 5Q0I, 5Q11, 4OIV, 6A5Y, 3P88, 5Q13, 5WZX, 1OSH, 6ITM, 3HC5, 5ICK, 5Q0U, 5Q0T, 5Q1F, 3GD2, 3L1B

ZINC - Investigational

NR1H4_HUMAN

ZINC - Metabolites

NR1H4_HUMAN

HPA

ENSG00000012504-NR1H4

GeneCards

NR1H4

Pharos - Targets

Q96RI1

Orphanet

NR1H4

ZINC - Predictions - Purchasable

NR1H4_HUMAN

HMDB Protein

HMDBP02506

Interactors (8)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q8WTS6 SETD7	1	SETD7 [nucleoplasm] (R-HSA-1183221)	0.633	5
UniProt:Q15788 NCOA1	3	NCOA1 [nucleoplasm] (R-HSA-442496) NCOA1 (868-1441) [nucleoplasm] (R-HSA-5603230) monoSUMO1-K732,K774-NCOA1 [nucleoplasm] (R-HSA-4085291)	0.558	4
UniProt:FGF19 ENSG00000162344			0.527	2
UniProt:O75151 PHF2	1	PHF2 [nucleoplasm] (R-HSA-5423093)	0.525	2
IntAct:EBI-11173918 IR1			0.524	2
IntAct:EBI-11173879 P1			0.524	4
IntAct:EBI-11173957 P4			0.524	4
IntAct:EBI-11173936 P2			0.524	4

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