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HDAC8 [nucleoplasm]
Stable Identifier
R-HSA-3004556
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Histone deacetylase 8, HDAC8_HUMAN
Locations in the PathwayBrowser
Expand all
Chromatin organization (Homo sapiens)
Chromatin modifying enzymes (Homo sapiens)
HDACs deacetylate histones (Homo sapiens)
HDAC8 deacetylates histones (Homo sapiens)
HDAC8 [nucleoplasm] (Homo sapiens)
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
Signaling by NOTCH1 in Cancer (Homo sapiens)
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer (Homo sapiens)
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants (Homo sapiens)
NICD1 PEST domain mutants displace co-repressor complex from RBPJ (CSL) (Homo sapiens)
NCOR:HDAC:TBL1 [nucleoplasm] (Homo sapiens)
HDAC [nucleoplasm] (Homo sapiens)
HDAC8 [nucleoplasm] (Homo sapiens)
RBPJ:NCOR corepressor complex [nucleoplasm] (Homo sapiens)
HDAC [nucleoplasm] (Homo sapiens)
HDAC8 [nucleoplasm] (Homo sapiens)
Signaling by NOTCH1 PEST Domain Mutants in Cancer (Homo sapiens)
Constitutive Signaling by NOTCH1 PEST Domain Mutants (Homo sapiens)
NICD1 PEST domain mutants displace co-repressor complex from RBPJ (CSL) (Homo sapiens)
NCOR:HDAC:TBL1 [nucleoplasm] (Homo sapiens)
HDAC [nucleoplasm] (Homo sapiens)
HDAC8 [nucleoplasm] (Homo sapiens)
RBPJ:NCOR corepressor complex [nucleoplasm] (Homo sapiens)
HDAC [nucleoplasm] (Homo sapiens)
HDAC8 [nucleoplasm] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Notch-HLH transcription pathway (Homo sapiens)
Formation of CSL NCOR corepressor complex (Homo sapiens)
HDAC [nucleoplasm] (Homo sapiens)
HDAC8 [nucleoplasm] (Homo sapiens)
RBPJ:NCOR corepressor complex [nucleoplasm] (Homo sapiens)
HDAC [nucleoplasm] (Homo sapiens)
HDAC8 [nucleoplasm] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by NOTCH (Homo sapiens)
Signaling by NOTCH1 (Homo sapiens)
NOTCH1 Intracellular Domain Regulates Transcription (Homo sapiens)
NICD1 displaces co-repressor complex from RBPJ (CSL) (Homo sapiens)
NCOR:HDAC:TBL1 [nucleoplasm] (Homo sapiens)
HDAC [nucleoplasm] (Homo sapiens)
HDAC8 [nucleoplasm] (Homo sapiens)
RBPJ:NCOR corepressor complex [nucleoplasm] (Homo sapiens)
HDAC [nucleoplasm] (Homo sapiens)
HDAC8 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9BY41 HDAC8
Gene Names
HDAC8, HDACL1, CDA07
Chain
chain:1-377
Reference Genes
BioGPS Gene:55869 HDAC8
COSMIC (genes):HDAC8 HDAC8
CTD Gene:55869 HDAC8
dbSNP Gene:55869 HDAC8
ENSEMBL:ENSG00000147099 HDAC8
HGNC:13315 HDAC8
KEGG:hsa:55869 HDAC8
Monarch:55869 HDAC8
NCBI Gene:55869 HDAC8
OMIM:300269 HDAC8
UCSC:Q9BY41 HDAC8
Reference Transcript
RefSeq:NM_001166422.2 HDAC8
RefSeq:NM_001166419.2 HDAC8
RefSeq:NM_018486.3 HDAC8
RefSeq:NM_001166448.2 HDAC8
RefSeq:NM_001166418.2 HDAC8
RefSeq:NM_001166420.2 HDAC8
Participates
as a candidate of
HDAC [nucleoplasm] (Homo sapiens)
Inferred To
hdaA [nucleoplasm]
(Dictyostelium discoideum)
HDAC8 [nucleoplasm]
(Bos taurus)
HDAC8 [nucleoplasm]
(Canis familiaris)
HDAC8 [nucleoplasm]
(Gallus gallus)
HDAC8 [nucleoplasm]
(Plasmodium falciparum)
HDAC8 [nucleoplasm]
(Sus scrofa)
hdac8 [nucleoplasm]
(Danio rerio)
hdac8 [nucleoplasm]
(Xenopus tropicalis)
HOS1 [nucleoplasm]
(Saccharomyces cerevisiae)
Hdac8 [nucleoplasm]
(Mus musculus)
Hdac8 [nucleoplasm]
(Rattus norvegicus)
Cross References
RefSeq
NP_060956.1
,
NP_001159890.1
,
NP_001159891.1
,
NP_001159892.1
,
NP_001159920.1
,
NP_001159894.1
ZINC - World Drugs
HDAC8_HUMAN
Guide to Pharmacology - Targets
2619
OpenTargets
ENSG00000147099
ENSEMBL
ENSP00000362655
,
ENST00000373573
,
ENSP00000497925
,
ENST00000439122
,
ENST00000373589
,
ENSG00000147099
,
ENST00000373559
,
ENSP00000362691
,
ENST00000373554
,
ENSP00000362674
,
ENSP00000362660
,
ENST00000373556
,
ENSP00000414486
,
ENSP00000362657
,
ENST00000649116
ZINC - FDA approved
HDAC8_HUMAN
ZINC - Substances
HDAC8_HUMAN
ZINC - Biogenic
HDAC8_HUMAN
ZINC target
Q9BY41
PRO
Q9BY41
GlyGen
Q9BY41
PDB
3EZT
,
3F07
,
5D1B
,
2V5W
,
3EZP
,
4QA3
,
1T67
,
5DC5
,
4RN1
,
3SFF
,
4QA7
,
7JVV
,
4RN2
,
5DC6
,
5BWZ
,
1VKG
,
3MZ3
,
1W22
,
5THS
,
7JVU
,
3MZ6
,
4QA0
,
3MZ7
,
5THU
,
3EW8
,
2V5X
,
3F06
,
5D1C
,
3F0R
,
6HSK
,
5D1D
,
3EWF
,
1T64
,
7JVW
,
4QA6
,
4QA1
,
4QA2
,
4RN0
,
1T69
,
3RQD
,
5DC8
,
3SFH
,
5DC7
,
5THT
,
5VI6
,
5FCW
,
6ODA
,
4QA5
,
6ODB
,
3MZ4
,
4QA4
,
6ODC
,
5THV
ZINC - Investigational
HDAC8_HUMAN
ZINC - Metabolites
HDAC8_HUMAN
HPA
ENSG00000147099-HDAC8
GeneCards
HDAC8
Pharos - Targets
Q9BY41
Orphanet
HDAC8
ZINC - Predictions - Purchasable
HDAC8_HUMAN
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