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HDAC8 [nucleoplasm]
Stable Identifier
R-HSA-3004556
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Histone deacetylase 8, HDAC8_HUMAN
Locations in the PathwayBrowser
Expand all
Chromatin organization (Homo sapiens)
Chromatin modifying enzymes (Homo sapiens)
HDACs deacetylate histones (Homo sapiens)
HDAC8 deacetylates histones (Homo sapiens)
HDAC8 [nucleoplasm] (Homo sapiens)
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
Signaling by NOTCH1 in Cancer (Homo sapiens)
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer (Homo sapiens)
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants (Homo sapiens)
NICD1 PEST domain mutants displace co-repressor complex from RBPJ (CSL) (Homo sapiens)
NCOR:HDAC:TBL1 [nucleoplasm] (Homo sapiens)
HDAC [nucleoplasm] (Homo sapiens)
HDAC8 [nucleoplasm] (Homo sapiens)
RBPJ:NCOR corepressor complex [nucleoplasm] (Homo sapiens)
HDAC [nucleoplasm] (Homo sapiens)
HDAC8 [nucleoplasm] (Homo sapiens)
Signaling by NOTCH1 PEST Domain Mutants in Cancer (Homo sapiens)
Constitutive Signaling by NOTCH1 PEST Domain Mutants (Homo sapiens)
NICD1 PEST domain mutants displace co-repressor complex from RBPJ (CSL) (Homo sapiens)
NCOR:HDAC:TBL1 [nucleoplasm] (Homo sapiens)
HDAC [nucleoplasm] (Homo sapiens)
HDAC8 [nucleoplasm] (Homo sapiens)
RBPJ:NCOR corepressor complex [nucleoplasm] (Homo sapiens)
HDAC [nucleoplasm] (Homo sapiens)
HDAC8 [nucleoplasm] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Notch-HLH transcription pathway (Homo sapiens)
Formation of CSL NCOR corepressor complex (Homo sapiens)
HDAC [nucleoplasm] (Homo sapiens)
HDAC8 [nucleoplasm] (Homo sapiens)
RBPJ:NCOR corepressor complex [nucleoplasm] (Homo sapiens)
HDAC [nucleoplasm] (Homo sapiens)
HDAC8 [nucleoplasm] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by NOTCH (Homo sapiens)
Signaling by NOTCH1 (Homo sapiens)
NOTCH1 Intracellular Domain Regulates Transcription (Homo sapiens)
NICD1 displaces co-repressor complex from RBPJ (CSL) (Homo sapiens)
NCOR:HDAC:TBL1 [nucleoplasm] (Homo sapiens)
HDAC [nucleoplasm] (Homo sapiens)
HDAC8 [nucleoplasm] (Homo sapiens)
RBPJ:NCOR corepressor complex [nucleoplasm] (Homo sapiens)
HDAC [nucleoplasm] (Homo sapiens)
HDAC8 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9BY41 HDAC8
Gene Names
HDAC8, HDACL1, CDA07
Chain
chain:1-377
Reference Genes
BioGPS Gene:55869 HDAC8
COSMIC (genes):HDAC8 HDAC8
CTD Gene:55869 HDAC8
dbSNP Gene:55869 HDAC8
ENSEMBL:ENSG00000147099.21 HDAC8
HGNC:13315 HDAC8
KEGG Gene (Homo sapiens):55869 HDAC8
Monarch:55869 HDAC8
NCBI Gene:55869 HDAC8
OMIM:300269 HDAC8
UCSC:Q9BY41 HDAC8
Reference Transcript
RefSeq:NM_001166422.1 HDAC8
RefSeq:NM_001166418.1 HDAC8
RefSeq:NM_001166420.1 HDAC8
RefSeq:NM_001166419.1 HDAC8
RefSeq:NM_001166448.1 HDAC8
RefSeq:NM_018486.2 HDAC8
Other Identifiers
11720592_a_at
11745329_a_at
11749936_a_at
11750486_x_at
11753151_a_at
11759948_x_at
11760130_a_at
17112032
223345_PM_at
223345_at
223908_PM_at
223908_at
223909_PM_s_at
223909_s_at
4012205
4012218
4012242
4012243
4012244
4012245
4012247
4012248
4012250
4012251
4012252
4012257
4012258
4012259
4012260
4012280
4012281
4012282
4012283
4012284
4012285
4012287
4012288
4012289
4012290
55869
57005_at
77775_at
79546_at
8173531
A_33_P3296789
A_33_P3296807
GE62453
GO:0000118
GO:0000122
GO:0000228
GO:0004407
GO:0005515
GO:0005622
GO:0005634
GO:0005654
GO:0005694
GO:0005737
GO:0006325
GO:0006351
GO:0006355
GO:0006357
GO:0007059
GO:0007062
GO:0016575
GO:0016787
GO:0030544
GO:0031397
GO:0031647
GO:0032200
GO:0032204
GO:0032991
GO:0033558
GO:0036211
GO:0043226
GO:0046872
GO:0051879
GO:0071922
GO:0140096
GO:0140297
GO:0160008
GO:0160009
HMNXSV003013660
HMNXSV003020753
HMNXSV003033478
HMNXSV003039369
ILMN_1651544
PH_hs_0006153
PH_hs_0035529
g13182768_3p_a_at
g13182768_3p_at
g8118720_3p_at
Participates
as a candidate of
HDAC [nucleoplasm] (Homo sapiens)
Inferred To
HDAC8 [nucleoplasm]
(Bos taurus)
HDAC8 [nucleoplasm]
(Canis familiaris)
HDAC8 [nucleoplasm]
(Danio rerio)
HDAC8 [nucleoplasm]
(Gallus gallus)
HDAC8 [nucleoplasm]
(Mus musculus)
HDAC8 [nucleoplasm]
(Rattus norvegicus)
HDAC8 [nucleoplasm]
(Sus scrofa)
Cross References
RefSeq
NP_001159892.1
,
NP_001159890.1
,
NP_001159920.1
,
NP_001159891.1
,
NP_001159894.1
,
NP_060956.1
ZINC - World Drugs
HDAC8_HUMAN
Guide to Pharmacology - Targets
2619
OpenTargets
ENSG00000147099
ZINC - FDA approved
HDAC8_HUMAN
ZINC - Substances
HDAC8_HUMAN
ZINC - Biogenic
HDAC8_HUMAN
ZINC target
Q9BY41
PRO
Q9BY41
PDB
3RQD
,
4QA1
,
6ODC
,
5D1C
,
7JVW
,
5VI6
,
5DC5
,
4RN2
,
1T69
,
3EWF
,
5DC8
,
4RN1
,
3MZ7
,
7JVV
,
5BWZ
,
5THU
,
4RN0
,
3MZ6
,
5THT
,
4QA3
,
5THS
,
4QA6
,
2V5X
,
3F0R
,
5D1B
,
3SFH
,
1W22
,
5THV
,
3SFF
,
2V5W
,
3EZT
,
4QA0
,
4QA5
,
6ODB
,
7JVU
,
6HSK
,
1T67
,
4QA4
,
5FCW
,
5DC7
,
3EZP
,
6ODA
,
3MZ3
,
4QA7
,
3F06
,
4QA2
,
1T64
,
1VKG
,
5D1D
,
3F07
,
3MZ4
,
5DC6
,
3EW8
ZINC - Investigational
HDAC8_HUMAN
ZINC - Metabolites
HDAC8_HUMAN
IntEnz
3.5.1.98
HPA
ENSG00000147099-HDAC8
GeneCards
Q9BY41
Ensembl
ENSP00000362660
,
ENSP00000362674
,
ENST00000373559
,
ENSG00000147099
,
ENST00000373589
,
ENSP00000362691
,
ENSP00000497925
,
ENSP00000362655
,
ENST00000373556
,
ENST00000373554
,
ENST00000649116
,
ENSP00000362657
,
ENSP00000414486
,
ENST00000373573
,
ENST00000439122
Pharos - Targets
Q9BY41
ZINC - Predictions - Purchasable
HDAC8_HUMAN
Orphanet
20779
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