Phosphorylated BORA binds SCF-beta-TrCp1/2

Stable Identifier
R-HSA-3000339
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The substrate recognition subunits beta-TrCP (BTRC) and beta-TrCP2 (FBXW11) of SCF-beta-TrPC1 and SCF-beta-TrPC2 ubiquitin ligases, respectively, bind the phosphorylated DSGYNT motif of BORA (Seki et al. 2008).

Literature References
PubMed ID Title Journal Year
18378770 Plk1- and beta-TrCP-dependent degradation of Bora controls mitotic progression

Seki, A, Coppinger, JA, Du, H, Jang, CY, Yates, JR, Fang, G

J. Cell Biol. 2008
Participants
Participant Of
Orthologous Events
Authored
Reviewed
Created