Reactome | AURKA phosphorylates PLK1

AURKA phosphorylates PLK1

Stable Identifier

R-HSA-3000310

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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AURKA (Aurora A kinase) phosphorylates PLK1 on threonine residue T210 that lies in the conserved aurora kinase consensus site (Seki et al. 2008). PLK1 needs to be phosphorylated on T210 to become catalytically active (Jang et al. 2002). BORA, but not other AURKA co-activators, facilitate PLK1 phosphorylation by AURKA (Macurek et al. 2008, Seki et al. 2008).

Literature References

PubMed ID	Title	Journal	Year
18566290	Bora and the kinase Aurora a cooperatively activate the kinase Plk1 and control mitotic entry Seki, A, Coppinger, JA, Yates, JR, Jang, CY, Fang, G	Science	2008
12207013	Phosphorylation of threonine 210 and the role of serine 137 in the regulation of mammalian polo-like kinase Erikson, RL, Ma, S, Jang, YJ, Terada, Y	J. Biol. Chem.	2002
18615013	Polo-like kinase-1 is activated by aurora A to promote checkpoint recovery Clouin, C, Medema, RH, Taylor, SS, Freire, R, Lampson, MA, Klompmaker, R, Lim, D, Yaffe, MB, Lindqvist, A, Mac?rek, L	Nature	2008