AURKA phosphorylates PLK1

Stable Identifier
R-HSA-3000310
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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AURKA (Aurora A kinase) phosphorylates PLK1 on threonine residue T210 that lies in the conserved aurora kinase consensus site (Seki et al. 2008). PLK1 needs to be phosphorylated on T210 to become catalytically active (Jang et al. 2002). BORA, but not other AURKA co-activators, facilitate PLK1 phosphorylation by AURKA (Macurek et al. 2008, Seki et al. 2008).

Literature References
PubMed ID Title Journal Year
12207013 Phosphorylation of threonine 210 and the role of serine 137 in the regulation of mammalian polo-like kinase

Jang, YJ, Ma, S, Terada, Y, Erikson, RL

J. Biol. Chem. 2002
18566290 Bora and the kinase Aurora a cooperatively activate the kinase Plk1 and control mitotic entry

Seki, A, Coppinger, JA, Jang, CY, Yates, JR, Fang, G

Science 2008
18615013 Polo-like kinase-1 is activated by aurora A to promote checkpoint recovery

Mac?rek, L, Lindqvist, A, Lim, D, Lampson, MA, Klompmaker, R, Freire, R, Clouin, C, Taylor, SS, Yaffe, MB, Medema, RH

Nature 2008
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of Centrosome:p-T288-AURKA:p-S252-BORA:PLK1 [cytosol]
Physical Entity
Activity
Orthologous Events
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Reviewed
Created