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NSMCE2 [nucleoplasm]
Stable Identifier
R-HSA-2993759
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
E3 SUMO-protein ligase NSE2 ecNumber6.3.2.-/ecNumber, NSE2_HUMAN
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
SUMOylation (Homo sapiens)
SUMO E3 ligases SUMOylate target proteins (Homo sapiens)
SUMOylation of DNA damage response and repair proteins (Homo sapiens)
SMC5-SMC6 Complex SUMOylates Cohesin with SUMO1 (Homo sapiens)
NSMCE2 [nucleoplasm] (Homo sapiens)
SMC5-SMC6 Complex [nucleoplasm] (Homo sapiens)
NSMCE2 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q96MF7 NSMCE2
Gene Names
NSMCE2, C8orf36, MMS21
Chain
chain:1-247
Reference Genes
BioGPS Gene:286053 NSMCE2
COSMIC (genes):NSMCE2 NSMCE2
CTD Gene:286053 NSMCE2
dbSNP Gene:286053 NSMCE2
ENSEMBL:ENSG00000156831 NSMCE2
ENSEMBL:ENSG00000156831.8 NSMCE2
HGNC:26513 NSMCE2
KEGG Gene (Homo sapiens):286053 NSMCE2
Monarch:286053 NSMCE2
NCBI Gene:286053 NSMCE2
OMIM:617246 NSMCE2
UCSC:Q96MF7 NSMCE2
Reference Transcript
RefSeq:XM_011516975.1 NSMCE2
RefSeq:XM_017013331.1 NSMCE2
RefSeq:XM_005250876.4 NSMCE2
RefSeq:XM_011516974.2 NSMCE2
RefSeq:NM_173685.2 NSMCE2
RefSeq:XM_005250875.2 NSMCE2
Other Identifiers
11721042_at
17072580
226536_PM_at
226536_at
286053
3114881
3114882
3114883
3114884
3114887
3114889
3114890
3114904
3114905
3114912
3114975
3114976
3114979
3114980
46151_at
8148293
A_14_P118551
A_23_P422794
GE542599
GO:0000278
GO:0000722
GO:0000724
GO:0000781
GO:0003824
GO:0005515
GO:0005634
GO:0005654
GO:0005694
GO:0006281
GO:0006310
GO:0006974
GO:0007049
GO:0007059
GO:0008270
GO:0016604
GO:0016605
GO:0016740
GO:0016925
GO:0019789
GO:0030915
GO:0032200
GO:0032204
GO:0034184
GO:0036211
GO:0043226
GO:0045842
GO:0046872
GO:0051301
GO:0061665
GO:0090398
GO:0140014
GO:0140096
HMNXSV003034157
Hs.58609.0.S1_3p_at
ILMN_1693210
PH_hs_0016672
TC08002091.hg
Participates
as a component of
SMC5-SMC6 Complex [nucleoplasm] (Homo sapiens)
Inferred To
LOC564644 [nucleoplasm]
(Danio rerio)
nsmce2 [nucleoplasm]
(Xenopus tropicalis)
NSMCE2 [nucleoplasm]
(Bos taurus)
NSMCE2 [nucleoplasm]
(Caenorhabditis elegans)
NSMCE2 [nucleoplasm]
(Dictyostelium discoideum)
NSMCE2 [nucleoplasm]
(Gallus gallus)
NSMCE2 [nucleoplasm]
(Mus musculus)
NSMCE2 [nucleoplasm]
(Rattus norvegicus)
NSMCE2 [nucleoplasm]
(Saccharomyces cerevisiae)
NSMCE2 [nucleoplasm]
(Schizosaccharomyces pombe)
Cross References
RefSeq
XP_011515277.1
,
XP_005250932.1
,
XP_016868820.1
,
XP_005250933.1
,
XP_011515276.1
,
NP_775956.1
OpenTargets
ENSG00000156831
GeneCards
Q96MF7
HPA
ENSG00000156831-NSMCE2
Ensembl
ENST00000287437
,
ENST00000522563
,
ENSP00000430668
,
ENSP00000287437
,
ENSG00000156831
PRO
Q96MF7
Pharos - Targets
Q96MF7
Orphanet
23502
PDB
2YU4
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P40222 TXLNA
1
TXLNA [cytosol]
(R-HSA-449124)
0.718
6
UniProt:P06396 GSN
7
GSN(200-270) [extracellular region]
(R-HSA-976940)
GSN [secretory granule lumen]
(R-HSA-6801486)
GSN [extracellular region]
(R-HSA-6806510)
GSN [ficolin-1-rich granule lumen]
(R-HSA-6801465)
GSN(404-782) [cytosol]
(R-HSA-350272)
GSN(28-403) [cytosol]
(R-HSA-201618)
GSN [cytosol]
(R-HSA-350275)
0.556
3
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