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TH [cytosol]
Stable Identifier
R-HSA-2980863
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Tyrosine 3-monooxygenase ecNumber1.14.16.2/ecNumber, TY3H_HUMAN
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Metabolism of amino acids and derivatives (Homo sapiens)
Metabolism of amine-derived hormones (Homo sapiens)
Catecholamine biosynthesis (Homo sapiens)
Tyrosine is hydroxylated to dopa (Homo sapiens)
TH:Fe2+ [cytosol] (Homo sapiens)
TH [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P07101 TH
Gene Names
TH, TYH
Chain
chain:1-528
Reference Genes
BioGPS Gene:7054 TH
COSMIC (genes):TH TH
CTD Gene:7054 TH
dbSNP Gene:7054 TH
ENSEMBL:ENSG00000180176 TH
HGNC:11782 TH
KEGG:hsa:7054 TH
Monarch:7054 TH
NCBI Gene:7054 TH
OMIM:191290 TH
UCSC:P07101 TH
Reference Transcript
RefSeq:NM_199292.2 TH
RefSeq:XM_011520335.2 TH
RefSeq:NM_000360.3 TH
RefSeq:NM_199293.2 TH
Participates
as a component of
TH:Fe2+ [cytosol] (Homo sapiens)
Inferred To
TH [cytosol]
(Bos taurus)
TH [cytosol]
(Caenorhabditis elegans)
TH [cytosol]
(Canis familiaris)
TH [cytosol]
(Danio rerio)
TH [cytosol]
(Dictyostelium discoideum)
TH [cytosol]
(Drosophila melanogaster)
TH [cytosol]
(Gallus gallus)
TH [cytosol]
(Mus musculus)
TH [cytosol]
(Rattus norvegicus)
TH [cytosol]
(Sus scrofa)
TH [cytosol]
(Xenopus tropicalis)
Cross References
Guide to Pharmacology - Targets
1243
OpenTargets
ENSG00000180176
ENSEMBL
ENST00000352909
,
ENST00000333684
,
ENSG00000180176
,
ENSP00000370567
,
ENSP00000325951
,
ENSP00000370571
,
ENST00000381175
,
ENSP00000328814
,
ENST00000381178
ZINC - Substances
TY3H_HUMAN
ZINC target
P07101
ZINC - Biogenic
TY3H_HUMAN
PRO
P07101
PDB
2XSN
,
4J6S
,
6ZZU
,
7A2G
,
6ZVP
,
7PIM
,
6ZN2
ZINC - Metabolites
TY3H_HUMAN
IntEnz
1.14.16.2
HPA
ENSG00000180176-TH
GeneCards
TH
Pharos - Targets
P07101
ZINC - Predictions - Purchasable
TY3H_HUMAN
Orphanet
TH
HMDB Protein
HMDBP00273
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P63104 YWHAZ
2
YWHAZ [cytosol]
(R-HSA-206099)
YWHAZ [nucleoplasm]
(R-HSA-450469)
0.527
2
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