POU5F1 (OCT4), SOX2, NANOG bind the EPHA1 promoter

Stable Identifier
R-HSA-2972967
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
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POU5F1 (OCT4), SOX2, NANOG bind the EPHA1 promoter
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The EPHA1 gene is bound by POU5F1 (OCT4) (Boyer et al. 2005, Jin et al. 2007, Jung et al. 2010, Kunarso et al. 2010, Goke et al. 2011), SOX2 (Boyer et al. 2005, Lister et al. 2009), NANOG (Boyer et al. 2005, Lister et al. 2009, Kunarso et al. 2010) and expression of the EPHA1 mRNA is activated by POU5F1 (Babaie et al. 2007, Greber et al. 2007, Kunarso et al. 2010), SOX2 (Greber et al. 2007), and NANOG (Greber et al. 2007).

Literature References
PubMed ID Title Journal Year
20526341 Transposable elements have rewired the core regulatory network of human embryonic stem cells

Kunarso, G, Chia, NY, Jeyakani, J, Hwang, C, Lu, X, Chan, YS, Ng, HH, Bourque, G

Nat. Genet. 2010
19829295 Human DNA methylomes at base resolution show widespread epigenomic differences

Lister, R, Pelizzola, M, Dowen, RH, Hawkins, RD, Hon, G, Tonti-Filippini, J, Nery, JR, Lee, L, Ye, Z, Ngo, QM, Edsall, L, Antosiewicz-Bourget, J, Stewart, R, Ruotti, V, Millar, AH, Thomson, JA, Ren, B, Ecker, JR

Nature 2009
16153702 Core transcriptional regulatory circuitry in human embryonic stem cells

Boyer, LA, Lee, TI, Cole, MF, Johnstone, SE, Levine, SS, Zucker, JP, Guenther, MG, Kumar, RM, Murray, HL, Jenner, RG, Gifford, DK, Melton, DA, Jaenisch, R, Young, RA

Cell 2005
17567999 Identification of an OCT4 and SRY regulatory module using integrated computational and experimental genomics approaches

Jin, VX, O'Geen, H, Iyengar, S, Green, R, Farnham, PJ

Genome Res. 2007
17506876 Silencing of core transcription factors in human EC cells highlights the importance of autocrine FGF signaling for self-renewal

Greber, B, Lehrach, H, Adjaye, J

BMC Dev. Biol. 2007
22215994 Combinatorial binding in human and mouse embryonic stem cells identifies conserved enhancers active in early embryonic development

Göke, J, Jung, M, Behrens, S, Chavez, L, O'Keeffe, S, Timmermann, B, Lehrach, H, Adjaye, J, Vingron, M

PLoS Comput. Biol. 2011
20505756 A data integration approach to mapping OCT4 gene regulatory networks operative in embryonic stem cells and embryonal carcinoma cells

Jung, M, Peterson, H, Chavez, L, Kahlem, P, Lehrach, H, Vilo, J, Adjaye, J

PLoS One 2010
17068183 Analysis of Oct4-dependent transcriptional networks regulating self-renewal and pluripotency in human embryonic stem cells

Babaie, Y, Herwig, R, Greber, B, Brink, TC, Wruck, W, Groth, D, Lehrach, H, Burdon, T, Adjaye, J

Stem Cells 2007
Participants
Input
Output
Participant Of
hasEvent
Authored
May, B  (2013-01-03)
Reviewed
Wang, J  (2014-01-23)
Created
D'Eustachio, P  (2013-01-06)