Reactome | E-selectin binds E-selectin ligand

E-selectin binds E-selectin ligand

Stable Identifier

R-HSA-2870221

Type

Reaction

Species

Homo sapiens

Compartment

plasma membrane

Locations in the PathwayBrowser

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Summation

E-selectin is an adhesion molecule on the cell surface of endothelial cells. It participates in the binding of leukocytes to activated blood vascular endothelium during inflammation or metastasis (Haraldsen G et al. 1996). Leucocytes express E-selectin ligand 1 (ESL-1) and P-selectin glycoprotein ligand-1 (PCGL-1) which were identified as the ligands for E-selectin (Graves BJ et al 1994; Asa D et al 1995). E-selectin has been also implicated in mediating tissue-specific homing primitive hematopoietic progenitor cells (HPCs) into bone marrow (BM). PCGL-1, CD43, CD44 were shown to function as E-selectin ligands on human BM cells (Dimitroff CJ et al. 2001; Katayama Y et al. 2003; Merzaban JS et al. 2011).

Literature References

PubMed ID	Title	Journal	Year
21659548	Analysis of glycoprotein E-selectin ligands on human and mouse marrow cells enriched for hematopoietic stem/progenitor cells Merzaban, JS, Burdick, MM, Gadhoum, SZ, Dagia, NM, Chu, JT, Fuhlbrigge, RC, Sackstein, R	Blood	2011
7509040	Insight into E-selectin/ligand interaction from the crystal structure and mutagenesis of the lec/EGF domains Graves, BJ, Crowther, RL, Chandran, C, Rumberger, JM, Li, S, Huang, KS, Presky, DH, Familletti, PC, Wolitzky, BA, Burns, DK	Nature	1994