E-selectin binds E-selectin ligand

Stable Identifier
Reaction [binding]
Homo sapiens
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
E-selectin is an adhesion molecule on the cell surface of endothelial cells. It participates in the binding of leukocytes to activated blood vascular endothelium during inflammation or metastasis (Haraldsen G et al. 1996). Leucocytes express E-selectin ligand 1 (ESL-1) and P-selectin glycoprotein ligand-1 (PCGL-1) which were identified as the ligands for E-selectin (Graves BJ et al 1994; Asa D et al 1995). E-selectin has been also implicated in mediating tissue-specific homing primitive hematopoietic progenitor cells (HPCs) into bone marrow (BM). PCGL-1, CD43, CD44 were shown to function as E-selectin ligands on human BM cells (Dimitroff CJ et al. 2001; Katayama Y et al. 2003; Merzaban JS et al. 2011).
Literature References
PubMed ID Title Journal Year
7509040 Insight into E-selectin/ligand interaction from the crystal structure and mutagenesis of the lec/EGF domains

Presky, DH, Li, S, Burns, DK, Rumberger, JM, Huang, KS, Wolitzky, BA, Graves, BJ, Familletti, PC, Chandran, C, Crowther, RL

Nature 1994
21659548 Analysis of glycoprotein E-selectin ligands on human and mouse marrow cells enriched for hematopoietic stem/progenitor cells

Dagia, NM, Chu, JT, Sackstein, R, Fuhlbrigge, RC, Gadhoum, SZ, Merzaban, JS, Burdick, MM

Blood 2011
Orthologous Events
Cite Us!