E-selectin is an adhesion molecule on the cell surface of endothelial cells. It participates in the binding of leukocytes to activated blood vascular endothelium during inflammation or metastasis (Haraldsen G et al. 1996). Leucocytes express E-selectin ligand 1 (ESL-1) and P-selectin glycoprotein ligand-1 (PCGL-1) which were identified as the ligands for E-selectin (Graves BJ et al 1994; Asa D et al 1995). E-selectin has been also implicated in mediating tissue-specific homing primitive hematopoietic progenitor cells (HPCs) into bone marrow (BM). PCGL-1, CD43, CD44 were shown to function as E-selectin ligands on human BM cells (Dimitroff CJ et al. 2001; Katayama Y et al. 2003; Merzaban JS et al. 2011).
Presky, DH, Li, S, Burns, DK, Rumberger, JM, Huang, KS, Wolitzky, BA, Graves, BJ, Familletti, PC, Chandran, C, Crowther, RL
Dagia, NM, Chu, JT, Sackstein, R, Fuhlbrigge, RC, Gadhoum, SZ, Merzaban, JS, Burdick, MM
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