Reactome | E-selectin binds E-selectin ligand

E-selectin binds E-selectin ligand

Stable Identifier

R-HSA-2870221

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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E-selectin is an adhesion molecule on the cell surface of endothelial cells. It participates in the binding of leukocytes to activated blood vascular endothelium during inflammation or metastasis (Haraldsen G et al. 1996). Leucocytes express E-selectin ligand 1 (ESL-1) and P-selectin glycoprotein ligand-1 (PCGL-1) which were identified as the ligands for E-selectin (Graves BJ et al 1994; Asa D et al 1995). E-selectin has been also implicated in mediating tissue-specific homing primitive hematopoietic progenitor cells (HPCs) into bone marrow (BM). PCGL-1, CD43, CD44 were shown to function as E-selectin ligands on human BM cells (Dimitroff CJ et al. 2001; Katayama Y et al. 2003; Merzaban JS et al. 2011).

Literature References

PubMed ID	Title	Journal	Year
7509040	Insight into E-selectin/ligand interaction from the crystal structure and mutagenesis of the lec/EGF domains Presky, DH, Li, S, Burns, DK, Rumberger, JM, Huang, KS, Wolitzky, BA, Graves, BJ, Familletti, PC, Chandran, C, Crowther, RL	Nature	1994
21659548	Analysis of glycoprotein E-selectin ligands on human and mouse marrow cells enriched for hematopoietic stem/progenitor cells Dagia, NM, Chu, JT, Sackstein, R, Fuhlbrigge, RC, Gadhoum, SZ, Merzaban, JS, Burdick, MM	Blood	2011