Reactome | TTYH2/3 transport cytosolic Cl- to extracellular region

TTYH2/3 transport cytosolic Cl- to extracellular region

Stable Identifier

R-HSA-2744242

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, extracellular region, plasma membrane

ReviewStatus

5/5

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TTYH2/3 transport cytosolic Cl- to extracellular region

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Human homologues 2 and 3 (TTYH2 and 3) mediate the efflux of Cl- from cells in response to the increase in intracellular Ca2+ levels (Suzuki & Mizuno 2004, Suzuki 2006). All CLCAs contain a consensus cleavage motif which is recognised by an internal zincin metalloprotease domain within the N terminus. Self-proteolysis within the secretory pathway yields N- and C-terminal fragments, a step critical for CLCA activation of calcium-activated chloride channels (CaCCs) mediated through the N-terminal fragment (Yurtsever et al. 2012).

Literature References

PubMed ID	Title	Journal	Year
15010458	A novel human Cl(-) channel family related to Drosophila flightless locus Suzuki, M, Mizuno, A	J. Biol. Chem.	2004
16219661	The Drosophila tweety family: molecular candidates for large-conductance Ca2+-activated Cl- channels Suzuki, M	Exp. Physiol.	2006