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Oligomerization of p-CARMA1
Stable Identifier
R-HSA-2730902
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
plasma membrane
,
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
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Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Fc epsilon receptor (FCERI) signaling (Homo sapiens)
FCERI mediated NF-kB activation (Homo sapiens)
Oligomerization of p-CARMA1 (Homo sapiens)
General
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
CARMA1 phosphorylation initiates its oligomerization and the coiled-coil (CC) domain of CARMA1 is hypothesized to mediate this clustering (Tanner et al. 2007).
Literature References
PubMed ID
Title
Journal
Year
17428801
CARMA1 coiled-coil domain is involved in the oligomerization and subcellular localization of CARMA1 and is required for T cell receptor-induced NF-kappaB activation
Tanner, MJ
,
Lin, X
,
Gaffen, SL
,
Hanel, W
J Biol Chem
2007
Participants
Input
DAG:p-5Y-PKC-theta:p-S559,S652-CARMA1 [plasma membrane]
(Homo sapiens)
p-S559,S652-CARD11 [cytosol]
(Homo sapiens)
Output
DAG:p-5Y-PKC-theta:p-S552,S645-CARMA1 oligomer [plasma membrane]
(Homo sapiens)
Participates
as an event of
FCERI mediated NF-kB activation (Homo sapiens)
Orthologous Events
Oligomerization of p-CARMA1 (Bos taurus)
Oligomerization of p-CARMA1 (Canis familiaris)
Oligomerization of p-CARMA1 (Mus musculus)
Oligomerization of p-CARMA1 (Rattus norvegicus)
Oligomerization of p-CARMA1 (Sus scrofa)
Authored
Niarakis, A (2012-12-21)
Reviewed
Roncagalli, R (2013-02-13)
Created
Garapati, P V (2012-12-05)
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