Reactome | Oligomerization of p-CARMA1

Oligomerization of p-CARMA1

Stable Identifier

R-HSA-2730902

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

plasma membrane, cytosol

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General

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CARMA1 phosphorylation initiates its oligomerization and the coiled-coil (CC) domain of CARMA1 is hypothesized to mediate this clustering (Tanner et al. 2007).

Literature References

PubMed ID	Title	Journal	Year
17428801	CARMA1 coiled-coil domain is involved in the oligomerization and subcellular localization of CARMA1 and is required for T cell receptor-induced NF-kappaB activation Tanner, MJ, Hanel, W, Gaffen, SL, Lin, X	J Biol Chem	2007

Participants

Input

Output

DAG:p-5Y-PKC-theta:p-S552,S645-CARMA1 oligomer [plasma membrane] (Homo sapiens)

Participant Of

hasEvent

FCERI mediated NF-kB activation

Orthologous Events

Oligomerization of p-CARMA1 (Bos taurus)

Oligomerization of p-CARMA1 (Canis familiaris)

Oligomerization of p-CARMA1 (Danio rerio)

Oligomerization of p-CARMA1 (Gallus gallus)

Oligomerization of p-CARMA1 (Mus musculus)

Oligomerization of p-CARMA1 (Sus scrofa)

Oligomerization of p-CARMA1 (Xenopus tropicalis)

Authored

Niarakis, A (2012-12-21)

Reviewed

Roncagalli, R (2013-02-13)

Created

Garapati, P V (2012-12-05)