Phosphorylation of TEC kinases by p-SYK

Stable Identifier
Reaction [transition]
Homo sapiens
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BTK/ITK are activated in a two step model. In the first step they are recruited to the membrane by binding to PIP3 or, alternatively with other binding partners like SLP-76. Once at the membrane SYK or Src-kinases in the vicinity phosphorylates Y551 (Y512 in ITK) in the activation loop of the catalytic domain of BTK to fully activate it (Rawlings et al. 1996, Park et al. 1996, Kawakami et al. 1994).
Literature References
PubMed ID Title Journal Year
12573241 Identification of phosphorylation sites within the SH3 domains of Tec family tyrosine kinases

Bäckesjö, CM, Nore, BF, Smith, CI, Mattsson, PT, Hansson, H, Westlund, A, Antonsson, P, Rönnstrand, L, Lennartsson, J, Löw, P

Biochim. Biophys. Acta 2003
8629002 Activation of BTK by a phosphorylation mechanism initiated by SRC family kinases

Park, H, Witte, ON, Kato, RM, Lin, S, Kinet, JP, Fluckiger, AC, Scharenberg, AM, Wahl, MI, Rawlings, DJ

Science 1996
7518558 Tyrosine phosphorylation and activation of Bruton tyrosine kinase upon Fc epsilon RI cross-linking

Miura, T, Tsukada, S, Kawakami, T, Witte, ON, Yao, L, Kawakami, Y

Mol. Cell. Biol. 1994
8630736 Regulation of Btk function by a major autophosphorylation site within the SH3 domain

Park, H, Turck, CW, Witte, ON, Kinet, JP, Scharenberg, AM, Tam, C, Wahl, MI, Rawlings, DJ, Afar, DE

Immunity 1996
Catalyst Activity

protein tyrosine kinase activity of Clustered p:LYN:p-FCERI:IgE:allergen:p-6Y-SYK [plasma membrane]

Orthologous Events
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