Phosphorylation of TEC kinases by p-SYK

Stable Identifier
Reaction [transition]
Homo sapiens
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BTK/ITK are activated in a two step model. In the first step they are recruited to the membrane by binding to PIP3 or, alternatively with other binding partners like SLP-76. Once at the membrane SYK or Src-kinases in the vicinity phosphorylates Y551 (Y512 in ITK) in the activation loop of the catalytic domain of BTK to fully activate it (Rawlings et al. 1996, Park et al. 1996, Kawakami et al. 1994).

Literature References
PubMed ID Title Journal Year
8629002 Activation of BTK by a phosphorylation mechanism initiated by SRC family kinases

Rawlings, DJ, Scharenberg, AM, Park, H, Wahl, MI, Lin, S, Kato, RM, Fluckiger, AC, Witte, ON, Kinet, JP

Science 1996
12573241 Identification of phosphorylation sites within the SH3 domains of Tec family tyrosine kinases

Nore, BF, Mattsson, PT, Antonsson, P, Bäckesjö, CM, Westlund, A, Lennartsson, J, Hansson, H, Löw, P, Rönnstrand, L, Smith, CI

Biochim. Biophys. Acta 2003
7518558 Tyrosine phosphorylation and activation of Bruton tyrosine kinase upon Fc epsilon RI cross-linking

Kawakami, Y, Yao, L, Miura, T, Tsukada, S, Witte, ON, Kawakami, T

Mol. Cell. Biol. 1994
8630736 Regulation of Btk function by a major autophosphorylation site within the SH3 domain

Park, H, Wahl, MI, Afar, DE, Turck, CW, Rawlings, DJ, Tam, C, Scharenberg, AM, Kinet, JP, Witte, ON

Immunity 1996
Participant Of
Catalyst Activity
Catalyst Activity
protein tyrosine kinase activity of Clustered p:LYN:p-FCERI:IgE:allergin:p-6Y-SYK [plasma membrane]
Physical Entity
Orthologous Events
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