Signaling by NOTCH1 HD Domain Mutants in Cancer

Stable Identifier
R-HSA-2691230
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
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Signaling by NOTCH1 HD Domain Mutants in Cancer
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NOTCH1 heterodimerization domain mutations are frequently found in T-cell acute lymphoblastic leukemia (T-ALL) (Weng et al. 2004) and result in constitutive activity of NOTCH1 mutants (Malecki et al. 2006).
Literature References
PubMed ID Title Journal Year
15472075 Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia

Lee, W, Blacklow, SC, Silverman, LB, Look, AT, Sanchez-Irizarry, C, Aster, JC, Ferrando, AA, Weng, AP, Morris JP, 4th

Science 2004
16738328 Leukemia-associated mutations within the NOTCH1 heterodimerization domain fall into at least two distinct mechanistic classes

Mitchell, JL, Malecki, MJ, Blacklow, SC, Xu, ML, Sanchez-Irizarry, C, Aster, JC, Histen, G

Mol. Cell. Biol. 2006
Participants
Events
Participates
as an event of
Disease
Name Identifier Synonyms
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
T-cell acute lymphoblastic leukemia DOID:5603
Authored
Orlic-Milacic, M  (2013-01-04)
Reviewed
Haw, R  (2013-02-10)
Created
Orlic-Milacic, M  (2012-12-04)
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