Syndecans 1, 2, 4, (3) bind FGF2

Stable Identifier
R-HSA-2684507
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Syndecans have attached heparan sulfate (HS) and to a lesser extent chondroitin sulfate (CS) chains. These allow interactions with a large number of proteins, including heparin-binding growth factors such as fibroblast growth factors (FGFs), mediating interaction with FGF receptors (Kiefer et al. 1990, Bernfield & Hooper 1991, Steinfeld et al. 1996, Chua et al. 2004). Various enzymes involved in post-translational HS chain modifications produce unique binding motifs that selectively recognize different proteins (Tkachenko et al. 2005).

Literature References
PubMed ID Title Journal Year
8609172 Stimulation of fibroblast growth factor receptor-1 occupancy and signaling by cell surface-associated syndecans and glypican

Steinfeld, R, Van den Berghe, H, David, G

J. Cell Biol. 1996
Participants
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Orthologous Events
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