Phosphorylated LEPR Binds SOCS3

Stable Identifier
R-HSA-2672302
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane, cytosol
ReviewStatus
5/5
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Phosphorylated LEPR Binds SOCS3
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As inferred from mouse, SOCS3 binds LEPR at phosphotyrosine-986 and phosphotyrosine-1079. SOCS3 competes with SHP2 (PTPN11) for phosphotyrosine-986 and with STAT5 for phosphotyrosine-1079. SOCS3 expression is upregulated by leptin and SOCS3 downregulates prolonged leptin signaling, providing a feedback loop to limit leptin's action.
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as an event of
Inferred From
Phosphorylated Lepr Binds Socs3 (Mus musculus)
Authored
May, B  (2012-11-27)
Reviewed
Scherer, T  (2013-08-31)
Gonzalez-Perez, RR  (2013-10-26)
Created
May, B  (2012-11-27)
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