Phosphorylated LEPR Binds SOCS3

Stable Identifier
R-HSA-2672302
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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As inferred from mouse, SOCS3 binds LEPR at phosphotyrosine-986 and phosphotyrosine-1079. SOCS3 competes with SHP2 (PTPN11) for phosphotyrosine-986 and with STAT5 for phosphotyrosine-1079. SOCS3 expression is upregulated by leptin and SOCS3 downregulates prolonged leptin signaling, providing a feedback loop to limit leptin's action.

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