Reactome | ASIC4 [plasma membrane]

ASIC4 [plasma membrane]

Stable Identifier

R-HSA-2671913

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Acid-sensing ion channel 4, ASIC4_HUMAN

Locations in the PathwayBrowser for interactor UniProt:Q9UBV2 SEL1L

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External Reference Information

External Reference

UniProt:Q96FT7 ASIC4

Gene Names

ASIC4, ACCN4

Chain

chain:1-539

Reference Genes

BioGPS Gene:55515 ASIC4

COSMIC - genes:ASIC4 ASIC4

CTD Gene:55515 ASIC4

dbSNP Gene:55515 ASIC4

ENSEMBL:ENSG00000072182 ASIC4

HGNC:21263 ASIC4

KEGG:hsa:55515 ASIC4

Monarch:55515 ASIC4

NCBI Gene:55515 ASIC4

OMIM:606715 ASIC4

UCSC:Q96FT7 ASIC4

Reference Transcript

RefSeq:NM_182847.3 ASIC4

This entity regulates

Negatively

ASIC trimers:H+ transport extracellular Na+ to cytosol (Homo sapiens)

Inferred To

Homologues of ASIC4 [plasma membrane] (Caenorhabditis elegans)

acd-2 [plasma membrane] (Caenorhabditis elegans)

Asic4 [plasma membrane] (Mus musculus)

Asic4 [plasma membrane] (Rattus norvegicus)

acd-1 [plasma membrane] (Caenorhabditis elegans)

acd-4 [plasma membrane] (Caenorhabditis elegans)

delm-2 [plasma membrane] (Caenorhabditis elegans)

asic4 [plasma membrane] (Xenopus tropicalis)

ASIC4 [plasma membrane] (Bos taurus)

ASIC4 [plasma membrane] (Canis familiaris)

ASIC4 [plasma membrane] (Gallus gallus)

ASIC4 [plasma membrane] (Sus scrofa)

acd-3 [plasma membrane] (Caenorhabditis elegans)

acd-5 [plasma membrane] (Caenorhabditis elegans)

delm-1 [plasma membrane] (Caenorhabditis elegans)

asic4a [plasma membrane] (Danio rerio)

flr-1 [plasma membrane] (Caenorhabditis elegans)

Cross References

RefSeq

NP_878267.3

ENSEMBL

ENSG00000072182, ENST00000358078, ENSP00000350786, ENST00000347842, ENSP00000326627

OpenTargets

ENSG00000072182

GeneCards

ASIC4

HPA

ENSG00000072182-ASIC4

PRO

Q96FT7

Pharos - Targets

Q96FT7

GlyGen

Q96FT7

HMDB Protein

HMDBP09055

Interactors (12)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P32243-2 OTX2			0.556	3
UniProt:Q8IWB1 IPRI			0.527	3
UniProt:Q9HD20 ATP13A1	1	ATP13A1 [endoplasmic reticulum membrane] (R-HSA-939749)	0.527	2
UniProt:Q9NUQ7 UFSP2			0.527	2
UniProt:Q9H0V9 LMAN2L	3	LMAN2L [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-5689834) LMAN2L [ER to Golgi transport vesicle membrane] (R-HSA-5689832) LMAN2L [endoplasmic reticulum membrane] (R-HSA-5689469)	0.527	2
UniProt:Q8WZA1 POMGNT1	6	POMGNT1 [Golgi membrane] (R-HSA-5617040) POMGNT1 S550N [Golgi membrane] (R-HSA-5617094) POMGNT1 R605Vfs29 [Golgi membrane] (R-HSA-5617081) POMGNT1 R63 [Golgi membrane] (R-HSA-5617033) POMGNT1 W475* [Golgi membrane] (R-HSA-5617097) POMGNT1 P493R [Golgi membrane] (R-HSA-5617048)	0.527	3
UniProt:Q6ZNB6 NFXL1			0.527	2
UniProt:Q96IV0 NGLY1	1	NGLY1 [cytosol] (R-HSA-8850591)	0.527	2
UniProt:Q5SWX8 ODR4			0.527	2
UniProt:Q9UK22 FBXO2	1	FBXO2 [cytosol] (R-HSA-976044)	0.527	3
UniProt:Q86X29 LSR	1	LSR [plasma membrane] (R-HSA-8933138)	0.527	2
UniProt:Q9UBV2 SEL1L	1	SEL1L [endoplasmic reticulum membrane] (R-HSA-1911545)	0.527	2

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