JAK2 Phosphorylates STAT5 in Response to Leptin

Stable Identifier
R-HSA-2671829
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane, cytosol
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
JAK2 Phosphorylates STAT5 in Response to Leptin
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Phosphorylated JAK2 phosphorylates STAT5 (at phosphotyrosine-694 of STAT5A and probably at the homologous residue in STAT5B) while STAT5 and JAK2 are bound to LEPR (Briscoe et al. 2001).

Literature References
PubMed ID Title Journal Year
11448122 Leptin receptor long-form signalling in a human liver cell line

Tadayyon, M, Arch, JR, Briscoe, CP, Hanif, S

Cytokine 2001
Participants
Input
Output
Participates
as an event of
Catalyst Activity

protein tyrosine kinase activity of LEP:p-LEPR:p-JAK2:STAT5 [plasma membrane]

Physical Entity
LEP:p-LEPR:p-JAK2:STAT5 [plasma membrane] (Homo sapiens)
Activity
protein tyrosine kinase activity (GO:0004713)
Inferred From
Jak2 Phosphorylates Stat5 in Response to Leptin (Mus musculus)
Authored
May, B  (2012-11-15)
Reviewed
Scherer, T  (2013-08-31)
Gonzalez-Perez, RR  (2013-10-26)
Created
May, B  (2012-11-26)
Cite Us!