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KCNJ11 [plasma membrane]
Stable Identifier
R-HSA-265561
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Potassium Channel Kir6.2
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Disorders of transmembrane transporters (Homo sapiens)
ABC transporter disorders (Homo sapiens)
Defective ABCC8 can cause hypo- and hyper-glycemias (Homo sapiens)
Defective ABCC8 does not form functional KATP channels, causing hyperinsulinemic hypoglycemia (Homo sapiens)
KCNJ11 tetramer:ABCC8 mutants [plasma membrane] (Homo sapiens)
KCNJ11 [plasma membrane] (Homo sapiens)
Defective ABCC9 causes CMD10, ATFB12 and Cantu syndrome (Homo sapiens)
Defective ABCC9 (in KCNJ11:ABCC9) does not transport K+ from extracellular region to cytosol (Homo sapiens)
ABCC9 mutants:KCNJ11 [plasma membrane] (Homo sapiens)
KCNJ11 [plasma membrane] (Homo sapiens)
Metabolism (Homo sapiens)
Integration of energy metabolism (Homo sapiens)
Regulation of insulin secretion (Homo sapiens)
KCNJ11 tetramer:ABCC8 tetramer binds 4xATP, closing the channel (Homo sapiens)
KCNJ11 [plasma membrane] (Homo sapiens)
KCNJ11 tetramer:ABCC8:Mg2+:ADP tetramer [plasma membrane] (Homo sapiens)
KCNJ11 [plasma membrane] (Homo sapiens)
KCNJ11:ATP tetramer:ABCC8 tetramer [plasma membrane] (Homo sapiens)
KCNJ11:ATP [plasma membrane] (Homo sapiens)
KCNJ11 [plasma membrane] (Homo sapiens)
Meglitinides bind ABCC8 (Homo sapiens)
ABCC8:Meglitinides [plasma membrane] (Homo sapiens)
KCNJ11 tetramer:ABCC8:Mg2+:ADP tetramer [plasma membrane] (Homo sapiens)
KCNJ11 [plasma membrane] (Homo sapiens)
KCNJ11 tetramer:ABCC8:Mg2+:ADP tetramer [plasma membrane] (Homo sapiens)
KCNJ11 [plasma membrane] (Homo sapiens)
SU drugs bind ABCC8 (in KCNJ11 tetramer:ABCC8:Mg2+:ADP tetramer) (Homo sapiens)
ABCC8:SU drugs [plasma membrane] (Homo sapiens)
KCNJ11 tetramer:ABCC8:Mg2+:ADP tetramer [plasma membrane] (Homo sapiens)
KCNJ11 [plasma membrane] (Homo sapiens)
KCNJ11 tetramer:ABCC8:Mg2+:ADP tetramer [plasma membrane] (Homo sapiens)
KCNJ11 [plasma membrane] (Homo sapiens)
Muscle contraction (Homo sapiens)
Cardiac conduction (Homo sapiens)
Ion homeostasis (Homo sapiens)
KCNJ11:ABCC9 binds nicorandil (Homo sapiens)
KCNJ11:ABCC9 [plasma membrane] (Homo sapiens)
KCNJ11 [plasma membrane] (Homo sapiens)
KCNJ11:ABCC9:nicorandil [plasma membrane] (Homo sapiens)
KCNJ11:ABCC9 [plasma membrane] (Homo sapiens)
KCNJ11 [plasma membrane] (Homo sapiens)
KCNJ11:ABCC9 transports K+ from extracellular region to cytosol (Homo sapiens)
KCNJ11:ABCC9 [plasma membrane] (Homo sapiens)
KCNJ11 [plasma membrane] (Homo sapiens)
Neuronal System (Homo sapiens)
Potassium Channels (Homo sapiens)
Inwardly rectifying K+ channels (Homo sapiens)
ATP sensitive Potassium channels (Homo sapiens)
Activation of ATP sensitive Potassium channels in muscle cells (Homo sapiens)
ATP sensitive K+ channels-inwardly rectifying (SUR2) [plasma membrane] (Homo sapiens)
ATP sensitive Potassium channels [plasma membrane] (Homo sapiens)
KCNJ11 [plasma membrane] (Homo sapiens)
Activation of ATP sensitive Potassium channels in neuroendocrine cells (Homo sapiens)
ATP sensitive K+ channels (SUR1) [plasma membrane] (Homo sapiens)
ATP sensitive Potassium channels [plasma membrane] (Homo sapiens)
KCNJ11 [plasma membrane] (Homo sapiens)
Transport of small molecules (Homo sapiens)
ABC-family proteins mediated transport (Homo sapiens)
KCNJ11:ABCC9 transports K+ from extracellular region to cytosol (Homo sapiens)
KCNJ11:ABCC9 [plasma membrane] (Homo sapiens)
KCNJ11 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q14654 KCNJ11
Gene Names
KCNJ11
Chain
chain:1-390
Reference Genes
BioGPS Gene:3767 KCNJ11
COSMIC (genes):KCNJ11 KCNJ11
CTD Gene:3767 KCNJ11
dbSNP Gene:3767 KCNJ11
ENSEMBL:ENSG00000187486 KCNJ11
HGNC:6257 KCNJ11
KEGG Gene (Homo sapiens):3767 KCNJ11
Monarch:3767 KCNJ11
NCBI Gene:3767 KCNJ11
OMIM:600937 KCNJ11
UCSC:Q14654 KCNJ11
Reference Transcript
RefSeq:NM_001166290.1 KCNJ11
Other Identifiers
0000610494
11734293_a_at
11734294_at
11748661_a_at
16736268
231740_PM_at
231740_at
3364870
3364871
3364872
3364873
3364874
3364875
3364876
3364877
3767
67681_at
7946853
A_23_P1973
D50582_at
GE80922
GO:0003674
GO:0005242
GO:0005244
GO:0005249
GO:0005515
GO:0005524
GO:0005575
GO:0005886
GO:0005887
GO:0005975
GO:0006006
GO:0006810
GO:0006811
GO:0006813
GO:0007267
GO:0008092
GO:0008150
GO:0008282
GO:0009410
GO:0015031
GO:0015272
GO:0016020
GO:0016021
GO:0019829
GO:0022857
GO:0030315
GO:0030506
GO:0030955
GO:0032991
GO:0033198
GO:0034765
GO:0042391
GO:0043167
GO:0044281
GO:0044325
GO:0046676
GO:0050796
GO:0050877
GO:0055085
GO:0071805
GO:0098662
GO:0140657
GO:1990573
HMNXSV003017071
Hs.248141.0.S1_3p_at
ILMN_1699057
ILMN_1726679
PH_hs_0032311
TC11001456.hg
Participates
as a member of
ATP sensitive Potassium channels [plasma membrane] (Homo sapiens)
as a component of
KCNJ11:ATP [plasma membrane] (Homo sapiens)
KCNJ11 tetramer:ABCC8:Mg2+:ADP tetramer [plasma membrane] (Homo sapiens)
KCNJ11 tetramer:ABCC8 mutants [plasma membrane] (Homo sapiens)
ABCC9 mutants:KCNJ11 [plasma membrane] (Homo sapiens)
KCNJ11:ABCC9 [plasma membrane] (Homo sapiens)
Inferred To
Homologues of KCNJ11 [plasma membrane]
(Drosophila melanogaster)
KCNJ11 [plasma membrane]
(Bos taurus)
KCNJ11 [plasma membrane]
(Canis familiaris)
KCNJ11 [plasma membrane]
(Gallus gallus)
KCNJ11 [plasma membrane]
(Sus scrofa)
LOC116410223 [plasma membrane]
(Xenopus tropicalis)
Irk1 [plasma membrane]
(Drosophila melanogaster)
Irk3 [plasma membrane]
(Drosophila melanogaster)
Irk2 [plasma membrane]
(Drosophila melanogaster)
kcnj11 [plasma membrane]
(Danio rerio)
Kcnj11 [plasma membrane]
(Mus musculus)
Kcnj11 [plasma membrane]
(Rattus norvegicus)
Cross References
RefSeq
NP_001159762.1
Guide to Pharmacology - Targets
442
OpenTargets
ENSG00000187486
GeneCards
Q14654
HPA
ENSG00000187486-KCNJ11
ZINC target
Q14654
Ensembl
ENST00000339994
,
ENST00000528731
,
ENSP00000434755
,
ENSP00000345708
,
ENSG00000187486
PRO
Q14654
Pharos - Targets
Q14654
Orphanet
16292
HMDB Protein
HMDBP02918
PDB
6C3O
,
6C3P
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