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ABCG8 [plasma membrane]
Stable Identifier
R-HSA-265487
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Icon
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Disorders of transmembrane transporters (Homo sapiens)
ABC transporter disorders (Homo sapiens)
Defective ABCG5 causes sitosterolemia (Homo sapiens)
Defective ABCG5 (in ABCG5:ABCG8) does not transport sterols from cytosol to extracellular region (Homo sapiens)
mutant ABCG5:ABCG8 [plasma membrane] (Homo sapiens)
ABCG8 [plasma membrane] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Nuclear Receptors (Homo sapiens)
NR1H2 and NR1H3-mediated signaling (Homo sapiens)
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux (Homo sapiens)
Expression of ABCG8 regulated by NR1H2 or NR1H3 (Homo sapiens)
ABCG8 [plasma membrane] (Homo sapiens)
Transport of small molecules (Homo sapiens)
ABC-family proteins mediated transport (Homo sapiens)
ABC transporters in lipid homeostasis (Homo sapiens)
ABCG5:ABCG8 transports sterols from cytosol to extracellular region (Homo sapiens)
ABCG5:ABCG8 [plasma membrane] (Homo sapiens)
ABCG8 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9H221 ABCG8
Gene Names
ABCG8
Chain
chain:1-673
Reference Genes
BioGPS Gene:64241 ABCG8
COSMIC (genes):ABCG8 ABCG8
CTD Gene:64241 ABCG8
dbSNP Gene:64241 ABCG8
ENSEMBL:ENSG00000143921 ABCG8
HGNC:13887 ABCG8
KEGG:hsa:64241 ABCG8
Monarch:64241 ABCG8
NCBI Gene:64241 ABCG8
OMIM:605460 ABCG8
UCSC:Q9H221 ABCG8
Reference Transcript
RefSeq:XM_005264483.3 ABCG8
RefSeq:NM_022437.2 ABCG8
Other Identifiers
11737339_at
16879564
231751_PM_at
231751_at
2479561
2479562
2479563
2479565
2479566
2479567
2479568
2479569
2479575
2479576
2479577
2479578
2479579
2479580
2479581
2479587
2479588
2479589
2479590
2479591
2479592
2479593
2479594
2479595
2479596
2479597
2479598
2479599
2479601
51189_at
61060_at
64241
8041696
87663_at
A_14_P139266
A_23_P209251
A_23_P90577
A_32_P96748
A_33_P3361112
GE82687
GO:0003824
GO:0005215
GO:0005515
GO:0005524
GO:0005886
GO:0006869
GO:0007584
GO:0009410
GO:0010949
GO:0014850
GO:0015914
GO:0015918
GO:0016020
GO:0016324
GO:0016787
GO:0016887
GO:0022600
GO:0030299
GO:0031667
GO:0033344
GO:0042626
GO:0042632
GO:0043190
GO:0043235
GO:0045796
GO:0046872
GO:0046982
GO:0046983
GO:0055085
GO:0055092
GO:0070328
GO:0120020
GO:0140359
GO:0140657
HMNXSV003056934
Hs.302030.0.S1_3p_at
ILMN_1680309
ILMN_1823937
PH_hs_0024962
TC02000272.hg
Participates
as an output of
Expression of ABCG8 regulated by NR1H2 or NR1H3 (Homo sapiens)
as a component of
mutant ABCG5:ABCG8 [plasma membrane] (Homo sapiens)
ABCG5:ABCG8 [plasma membrane] (Homo sapiens)
Other forms of this molecule
ABCG8 Y658* [plasma membrane]
ABCG8 G574R [plasma membrane]
ABCG8 P231T [plasma membrane]
ABCG8 W361* [plasma membrane]
ABCG8 R263Q [plasma membrane]
ABCG8 D19H [plasma membrane]
Inferred To
CG18633 [plasma membrane]
(Drosophila melanogaster)
Homologues of ABCG8 [plasma membrane]
(Caenorhabditis elegans)
Homologues of ABCG8 [plasma membrane]
(Dictyostelium discoideum)
Homologues of ABCG8 [plasma membrane]
(Drosophila melanogaster)
ABCG8 [plasma membrane]
(Bos taurus)
ABCG8 [plasma membrane]
(Canis familiaris)
ABCG8 [plasma membrane]
(Dictyostelium discoideum)
ABCG8 [plasma membrane]
(Drosophila melanogaster)
ABCG8 [plasma membrane]
(Gallus gallus)
ABCG8 [plasma membrane]
(Plasmodium falciparum)
ABCG8 [plasma membrane]
(Saccharomyces cerevisiae)
ABCG8 [plasma membrane]
(Sus scrofa)
Abcg8 [plasma membrane]
(Mus musculus)
Abcg8 [plasma membrane]
(Rattus norvegicus)
wht-5 [plasma membrane]
(Caenorhabditis elegans)
abcx-1 [plasma membrane]
(Caenorhabditis elegans)
Cross References
Guide to Pharmacology - Targets
795
ENSEMBL
ENST00000272286
,
ENSP00000272286
OpenTargets
ENSG00000143921
HPA
ENSG00000143921-ABCG8
PRO
Q9H221
Pharos - Targets
Q9H221
GlyGen
Q9H221
Orphanet
ABCG8
PDB
8CUB
,
7JR7
,
7R87
,
7R8A
,
7R89
,
5DO7
,
7R8B
,
7R88
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q14696 MESD
0.556
3
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