Integrin alpha9beta1 is widely expressed on smooth muscle, epithelial cells, and highly and specifically expressed on neutrophils. VCAM-1 is one of the effective ligands for the integrin alpha9beta1. This interaction mediates the neutrophile migration on VCAM-1 and extravasation of neutrophils at sites of acute inflammation.
Yednock, T, Taooka, Y, Sheppard, D, Chen, J
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