Reactome | SPP1 (osteopontin) binds integrin alpha5beta1, alpha9beta1

SPP1 (osteopontin) binds integrin alpha5beta1, alpha9beta1

Stable Identifier

R-HSA-265424

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

ReviewStatus

5/5

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SPP1 (osteopontin) binds integrin alpha5beta1, alpha9beta1

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Osteopontin (SPP1) is a highly phosphorylated sialoprotein that is a prominent component of the mineralized extracellular matrices of bones and teeth. It provides an adhesive matrix for endothelial and smooth muscle cells during remodeling of the vascular wall following injury. SPP1 binds multiple integrins including alphaVbeta3, alphaVbeta1 and alphaVbeta5 (Liaw et al. 1995), alpha5beta1 (Barry et al. 2000), alpha9beta1 (Smith et al. 1996, Yokosaki et al. 1999) alpha4beta1 (Bayless et al. 1998), alpha8beta1 (Denda et al. 1998) and the receptor CD44 (Katagiri et al. 1999). Integrin alpha4beta1 is expressed on leukocytes, differentiated vascular smooth muscle cells and tumor cells. It has been shown to mediate leukocyte attachment to OPN.

Literature References

PubMed ID	Title	Journal	Year
10673366	A regulated interaction between alpha5beta1 integrin and osteopontin Barry, ST, Ludbrook, SB, Murrison, E, Horgan, CM	Biochem Biophys Res Commun	2000
8910476	Osteopontin N-terminal domain contains a cryptic adhesive sequence recognized by alpha9beta1 integrin Smith, LL, Cheung, HK, Ling, LE, Chen, J, Sheppard, D, Pytela, R, Giachelli, CM	J Biol Chem	1996
10593924	The integrin alpha(9)beta(1) binds to a novel recognition sequence (SVVYGLR) in the thrombin-cleaved amino-terminal fragment of osteopontin Yokosaki, Y, Matsuura, N, Sasaki, T, Murakami, I, Schneider, H, Higashiyama, S, Saitoh, Y, Yamakido, M, Taooka, Y, Sheppard, D	J Biol Chem	1999