SPP1 (osteopontin) binds integrin alpha5beta1, alpha9beta1

Stable Identifier
Reaction [binding]
Homo sapiens
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Osteopontin (SPP1) is a highly phosphorylated sialoprotein that is a prominent component of the mineralized extracellular matrices of bones and teeth. It provides an adhesive matrix for endothelial and smooth muscle cells during remodeling of the vascular wall following injury. SPP1 binds multiple integrins including alphaVbeta3, alphaVbeta1 and alphaVbeta5 (Liaw et al. 1995), alpha5beta1 (Barry et al. 2000), alpha9beta1 (Smith et al. 1996, Yokosaki et al. 1999) alpha4beta1 (Bayless et al. 1998), alpha8beta1 (Denda et al. 1998) and the receptor CD44 (Katagiri et al. 1999). Integrin alpha4beta1 is expressed on leukocytes, differentiated vascular smooth muscle cells and tumor cells. It has been shown to mediate leukocyte attachment to OPN.
Literature References
PubMed ID Title Journal Year
10673366 A regulated interaction between alpha5beta1 integrin and osteopontin

Horgan, CM, Murrison, E, Barry, ST, Ludbrook, SB

Biochem Biophys Res Commun 2000
8910476 Osteopontin N-terminal domain contains a cryptic adhesive sequence recognized by alpha9beta1 integrin

Giachelli, CM, Ling, LE, Cheung, HK, Pytela, R, Chen, J, Smith, LL, Sheppard, D

J Biol Chem 1996
10593924 The integrin alpha(9)beta(1) binds to a novel recognition sequence (SVVYGLR) in the thrombin-cleaved amino-terminal fragment of osteopontin

Yamakido, M, Sasaki, T, Saitoh, Y, Murakami, I, Matsuura, N, Taooka, Y, Higashiyama, S, Schneider, H, Yokosaki, Y, Sheppard, D

J Biol Chem 1999
Orthologous Events
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