Interaction of integrin alphaEbeta7 with Cadherin-1

Stable Identifier
R-HSA-265422
Type
Reaction [binding]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
E-cadherin, memeber of the cadherin superfamily is a calcium-dependent cell adhesion protein expressed on the epithelial cells. The integrin alphaEbeta7 is selectively expressed on intestinal intraepithelial T lymphocytes and CD8+ T lymphocytes in inflammatory lesions near epithelial cells. E-cadherin undergoes both homophilic and heterophilic interactions. It is the only binding partner for alphaEbeta7. This interaction plays a key role in the proliferation of intrathymic T cell populations, T lymphocyte development and damage of target epithelia.
Literature References
PubMed ID Title Journal Year
15330449 Functional assessment of alphaEbeta7/E-cadherin interactions in the steady state postnatal thymus

Petrie, HT, Prockop, SE

Clin Dev Immunol 2004
16002701 Critical role of the fifth domain of E-cadherin for heterophilic adhesion with alpha E beta 7, but not for homophilic adhesion

Tsuzaka, K, Abe, T, Nozaki, K, Yoshimoto, K, Kumazawa, C, Tsubota, K, Shiraishi, K, Takeuchi, T

J Immunol 2005
Participants
Participates
Orthologous Events
Authored
Reviewed
Created
Cite Us!