Reactome | Interaction of integrin alphaEbeta7 with Cadherin-1

Interaction of integrin alphaEbeta7 with Cadherin-1

Stable Identifier

R-HSA-265422

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Interaction of integrin alphaEbeta7 with Cadherin-1

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

E-cadherin, memeber of the cadherin superfamily is a calcium-dependent cell adhesion protein expressed on the epithelial cells. The integrin alphaEbeta7 is selectively expressed on intestinal intraepithelial T lymphocytes and CD8+ T lymphocytes in inflammatory lesions near epithelial cells. E-cadherin undergoes both homophilic and heterophilic interactions. It is the only binding partner for alphaEbeta7. This interaction plays a key role in the proliferation of intrathymic T cell populations, T lymphocyte development and damage of target epithelia.

Literature References

PubMed ID	Title	Journal	Year
15330449	Functional assessment of alphaEbeta7/E-cadherin interactions in the steady state postnatal thymus Petrie, HT, Prockop, SE	Clin Dev Immunol	2004
16002701	Critical role of the fifth domain of E-cadherin for heterophilic adhesion with alpha E beta 7, but not for homophilic adhesion Tsuzaka, K, Abe, T, Nozaki, K, Yoshimoto, K, Kumazawa, C, Tsubota, K, Shiraishi, K, Takeuchi, T	J Immunol	2005