Reactome | Corticotropin cleavage from POMC

Corticotropin cleavage from POMC

Stable Identifier

R-HSA-265301

Type

Reaction [transition]

Species

Homo sapiens

Compartment

secretory granule lumen

ReviewStatus

5/5

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Corticotropin (adrenocorticotropic hormone, ACTH) is a 39-amino acid polypeptide hormone produced and secreted by the pituitary gland. It is often produced in response to biological stress (along with corticotropin-releasing hormone). Its principal effects are increased production of androgens and cortisol. Corticotropin is processed from the precursor pro-opiomelanocortin (POMC). The enzyme that performs the cleavage of POMC to corticotropin is prohormone convertase 1 (PC1). In addition to corticotropin, POMC is processed into other small, biologically active fragments. These include lipotropins, melanocyte-stimulating hormone and endorphins.

Literature References

PubMed ID	Title	Journal	Year
14463577	On the structure of human corticotropin (adrenocorticotropic hormone) Lee, TH, Lerner, AB, Buettner-Janusch, V	J Biol Chem	1961
9207799	Obesity and impaired prohormone processing associated with mutations in the human prohormone convertase 1 gene Jackson, RS, Creemers, JW, Ohagi, S, Raffin-Sanson, ML, Sanders, L, Montague, CT, Hutton, JC, O'Rahilly, S	Nat Genet	1997