TIRAP binds PIP2-rich regions in the plasma membrane

Stable Identifier
R-HSA-2559456
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Synonyms
MAL binds PIP2-rich regions in the plasma membrane
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Upon LPS stimulation, Mal(TIRAP) was shown to bind to PIP2-rich regions on the cell surface trough its phosphatidylinositol 4,5-bisphosphate-binding domain [Kagan JC and Medzithov R 2007]. TLR2 or 4 associates with Mal(TIRAP) on the cell surface, which in turn facilitates the binding of MyD88 to the activated TLR, leading to NF-kB and MAPK activation [Nunez Miguel R et al 2007, Nagpal K et al 2009].

Literature References
PubMed ID Title Journal Year
16751103 Phosphoinositide-mediated adaptor recruitment controls Toll-like receptor signaling

Kagan, JC, Medzhitov, R

Cell 2006
11544529 Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction

Fitzgerald, KA, Palsson-McDermott, EM, Bowie, AG, Jefferies, CA, Mansell, AS, Brady, G, Brint, E, Dunne, A, Gray, P, Harte, MT, McMurray, D, Smith, DE, Sims, JE, Bird, TA, O'Neill, LA

Nature 2001
19509286 A TIR domain variant of MyD88 adapter-like (Mal)/TIRAP results in loss of MyD88 binding and reduced TLR2/TLR4 signaling

Nagpal, K, Plantinga, TS, Wong, J, Monks, BG, Gay, NJ, Netea, MG, Fitzgerald, KA, Golenbock, DT

J. Biol. Chem. 2009
15585605 TIRAP/Mal, TRIF and TRAM. Differential utilization of these TIR

Takeda, K, Akira, S

Int Immunol 2005
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