TIRAP binds PIP2-rich regions in the plasma membrane

Stable Identifier
R-HSA-2559456
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Synonyms
MAL binds PIP2-rich regions in the plasma membrane
ReviewStatus
5/5
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Upon LPS stimulation, Mal(TIRAP) was shown to bind to PIP2-rich regions on the cell surface trough its phosphatidylinositol 4,5-bisphosphate-binding domain [Kagan JC and Medzithov R 2007]. TLR2 or 4 associates with Mal(TIRAP) on the cell surface, which in turn facilitates the binding of MyD88 to the activated TLR, leading to NF-kB and MAPK activation [Nunez Miguel R et al 2007, Nagpal K et al 2009].
Literature References
PubMed ID Title Journal Year
11544529 Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction

Jefferies, CA, O'Neill, LA, Mansell, AS, Bird, TA, Brint, E, Smith, DE, Gray, P, Sims, JE, Palsson-McDermott, EM, Bowie, AG, Harte, MT, Fitzgerald, KA, McMurray, D, Dunne, A, Brady, G

Nature 2001
16751103 Phosphoinositide-mediated adaptor recruitment controls Toll-like receptor signaling

Kagan, JC, Medzhitov, R

Cell 2006
19509286 A TIR domain variant of MyD88 adapter-like (Mal)/TIRAP results in loss of MyD88 binding and reduced TLR2/TLR4 signaling

Plantinga, TS, Fitzgerald, KA, Netea, MG, Nagpal, K, Monks, BG, Wong, J, Gay, NJ, Golenbock, DT

J. Biol. Chem. 2009
15585605 TIRAP/Mal, TRIF and TRAM. Differential utilization of these TIR

Takeda, K, Akira, S

Int Immunol 2005
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