Reactome | TIRAP binds PIP2-rich regions in the plasma membrane

TIRAP binds PIP2-rich regions in the plasma membrane

Stable Identifier

R-HSA-2559456

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane, cytosol

Synonyms

MAL binds PIP2-rich regions in the plasma membrane

ReviewStatus

5/5

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TIRAP binds PIP2-rich regions in the plasma membrane

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Upon LPS stimulation, Mal(TIRAP) was shown to bind to PIP2-rich regions on the cell surface trough its phosphatidylinositol 4,5-bisphosphate-binding domain [Kagan JC and Medzithov R 2007]. TLR2 or 4 associates with Mal(TIRAP) on the cell surface, which in turn facilitates the binding of MyD88 to the activated TLR, leading to NF-kB and MAPK activation [Nunez Miguel R et al 2007, Nagpal K et al 2009].

Literature References

PubMed ID	Title	Journal	Year
11544529	Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction Fitzgerald, KA, Palsson-McDermott, EM, Bowie, AG, Jefferies, CA, Mansell, AS, Brady, G, Brint, E, Dunne, A, Gray, P, Harte, MT, McMurray, D, Smith, DE, Sims, JE, Bird, TA, O'Neill, LA	Nature	2001
16751103	Phosphoinositide-mediated adaptor recruitment controls Toll-like receptor signaling Kagan, JC, Medzhitov, R	Cell	2006
19509286	A TIR domain variant of MyD88 adapter-like (Mal)/TIRAP results in loss of MyD88 binding and reduced TLR2/TLR4 signaling Nagpal, K, Plantinga, TS, Wong, J, Monks, BG, Gay, NJ, Netea, MG, Fitzgerald, KA, Golenbock, DT	J. Biol. Chem.	2009
15585605	TIRAP/Mal, TRIF and TRAM. Differential utilization of these TIR Takeda, K, Akira, S	Int Immunol	2005