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Mitotic Metaphase and Anaphase
Stable Identifier
R-HSA-2555396
Type
Pathway
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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Cell Cycle (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
M Phase (Homo sapiens)
Mitotic Metaphase and Anaphase (Homo sapiens)
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Metaphase is marked by the formation of the metaphase plate. The metaphase plate is formed when the spindle fibers align the chromosomes along the middle of the cell. Such an organization helps to ensure that later, when the chromosomes are separated, each new nucleus that is formed receives one copy of each chromosome. This pathway has not yet been annotated in Reactome.
The metaphase to anaphase transition during mitosis is triggered by the destruction of mitotic cyclins.
In anaphase, the paired chromosomes separate at the centromeres, and move to the opposite sides of the cell. The movement of the chromosomes is facilitated by a combination of kinetochore movement along the spindle microtubules and through the physical interaction of polar microtubules.
Participants
Events
Mitotic Metaphase/Anaphase Transition
(Homo sapiens)
Mitotic Anaphase
(Homo sapiens)
Participates
as an event of
M Phase (Homo sapiens)
Orthologous Events
Mitotic Metaphase and Anaphase (Bos taurus)
Mitotic Metaphase and Anaphase (Caenorhabditis elegans)
Mitotic Metaphase and Anaphase (Canis familiaris)
Mitotic Metaphase and Anaphase (Danio rerio)
Mitotic Metaphase and Anaphase (Dictyostelium discoideum)
Mitotic Metaphase and Anaphase (Drosophila melanogaster)
Mitotic Metaphase and Anaphase (Gallus gallus)
Mitotic Metaphase and Anaphase (Mus musculus)
Mitotic Metaphase and Anaphase (Plasmodium falciparum)
Mitotic Metaphase and Anaphase (Rattus norvegicus)
Mitotic Metaphase and Anaphase (Saccharomyces cerevisiae)
Mitotic Metaphase and Anaphase (Schizosaccharomyces pombe)
Mitotic Metaphase and Anaphase (Sus scrofa)
Mitotic Metaphase and Anaphase (Xenopus tropicalis)
Created
Orlic-Milacic, M (2012-11-02)
© 2024
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