Deacetylation of cohesin

Stable Identifier
R-HSA-2545253
Type
Reaction
Species
Homo sapiens
Compartment
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HDAC8 deacetylates cohesin in prometaphase, after cohesin dissociates from chromosomal arms (Deardorff et al. 2012).

Literature References
PubMed ID Title Journal Year
22885700 HDAC8 mutations in Cornelia de Lange syndrome affect the cohesin acetylation cycle

Shirahige, K, Kiyono, T, Magnaghi-Jaulin, L, Clark, D, Katou, Y, Krantz, ID, Kaiser, FJ, Takagaki, K, Ernst, S, Nozaki, N, Siu, VM, Prigent, C, Christianson, DW, De Baere, E, Decroos, C, Francey, LJ, Di Donato, N, Bando, M, Saitoh, K, Kaur, M, Hirashima, K, Itoh, T, Suzuki, Y, Nakato, R, Mortier, GR, Seimiya, H, Wilde, JJ, Gillessen-Kaesbach, G, Jackson, LG, Watrin, E, Gyftodimou, Y, Willems, PJ, Lombardi, PM, Petersen, MB, Deardorff, MA, Ishikawa, Y, Minamino, M, Jaulin, C, Cole, KE, Hirota, T, Komata, M, Hullings, M

Nature 2012
Participants
Participates
Catalyst Activity

histone deacetylase activity of HDAC8 [cytosol]

Orthologous Events
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