Intracellular alkalinization is essential for the initiation of motility, capacitation, hyperactivation, and the acrosome reaction. Hv1 mediates the voltage-dependent proton permeability of excitable membranes. Hv1 is abundantly expressed in human sperm cells within the principal piece of the sperm flagellum, making it ideally positioned to activate pH-dependent proteins of the axoneme and thus to control sperm motility.
Botchkina, IL, Lishko, PV, Kirichok, Y, Fedorenko, A
voltage-gated cation channel activity of HV1 Channel [plasma membrane]
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