Hv1 Mediated H+ Permeability

Stable Identifier
R-HSA-2534378
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Intracellular alkalinization is essential for the initiation of motility, capacitation, hyperactivation, and the acrosome reaction. Hv1 mediates the voltage-dependent proton permeability of excitable membranes. Hv1 is abundantly expressed in human sperm cells within the principal piece of the sperm flagellum, making it ideally positioned to activate pH-dependent proteins of the axoneme and thus to control sperm motility.

Literature References
PubMed ID Title Journal Year
20144758 Acid extrusion from human spermatozoa is mediated by flagellar voltage-gated proton channel

Lishko, PV, Botchkina, IL, Fedorenko, A, Kirichok, Y

Cell 2010
Participants
Participates
Catalyst Activity

voltage-gated cation channel activity of HV1 Channel [plasma membrane]

Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created
Cite Us!