Hv1 Mediated H+ Permeability

Stable Identifier
R-HSA-2534378
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane
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Hv1 Mediated H+ Permeability
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Intracellular alkalinization is essential for the initiation of motility, capacitation, hyperactivation, and the acrosome reaction. Hv1 mediates the voltage-dependent proton permeability of excitable membranes. Hv1 is abundantly expressed in human sperm cells within the principal piece of the sperm flagellum, making it ideally positioned to activate pH-dependent proteins of the axoneme and thus to control sperm motility.

Literature References
PubMed ID Title Journal Year
20144758 Acid extrusion from human spermatozoa is mediated by flagellar voltage-gated proton channel

Lishko, PV, Botchkina, IL, Fedorenko, A, Kirichok, Y

Cell 2010
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
voltage-gated cation channel activity of HV1 Channel [plasma membrane]
Physical Entity
HV1 Channel [plasma membrane]
Activity
voltage-gated cation channel activity (0022843)
Orthologous Events
Hv1 Mediated H+ Permeability (Bos taurus)
Hv1 Mediated H+ Permeability (Canis familiaris)
Hv1 Mediated H+ Permeability (Danio rerio)
Hv1 Mediated H+ Permeability (Gallus gallus)
Hv1 Mediated H+ Permeability (Mus musculus)
Hv1 Mediated H+ Permeability (Rattus norvegicus)
Hv1 Mediated H+ Permeability (Sus scrofa)
Hv1 Mediated H+ Permeability (Xenopus tropicalis)
Authored
Gillespie, ME  (2013-02-13)
Reviewed
Lishko, PV  (2013-05-21)
Created
Gillespie, ME  (2012-10-25)
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