SPAM1 Binds Hyaluronic Acid

Stable Identifier
R-HSA-2534346
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
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SPAM1 Binds Hyaluronic Acid
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The fertilizing spermatozoon must penetrate the surrounding cumulus mass, (or cumulus oophorus), consisting of follicular cells dispersed in a polymerized matrix composed mainly of hyaluronic acid.

Literature References
PubMed ID Title Journal Year
8195297 A hyaluronidase activity of the sperm plasma membrane protein PH-20 enables sperm to penetrate the cumulus cell layer surrounding the egg

Myles, DG, Lathrop, WF, Mahan, K, Primakoff, P, Lin, Y

J Cell Biol 1994
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Output
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as an event of
Event Information
Go Biological Process
sperm-egg recognition (0035036)
Orthologous Events
SPAM1 Binds Hyaluronic Acid (Bos taurus)
SPAM1 Binds Hyaluronic Acid (Caenorhabditis elegans)
SPAM1 Binds Hyaluronic Acid (Canis familiaris)
SPAM1 Binds Hyaluronic Acid (Danio rerio)
SPAM1 Binds Hyaluronic Acid (Gallus gallus)
SPAM1 Binds Hyaluronic Acid (Mus musculus)
SPAM1 Binds Hyaluronic Acid (Rattus norvegicus)
SPAM1 Binds Hyaluronic Acid (Sus scrofa)
SPAM1 Binds Hyaluronic Acid (Xenopus tropicalis)
Authored
Gillespie, ME  (2013-02-13)
Reviewed
Lishko, PV  (2013-05-21)
Created
Gillespie, ME  (2012-10-25)
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