Reactome | cGMP dissociates from CNG channels

cGMP dissociates from CNG channels

Stable Identifier

R-HSA-2514865

Type

Reaction [dissociation]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

Synonyms

Decreased cGMP closes cation channels

ReviewStatus

5/5

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As cGMP is hydrolysed during the activation phase of phototransduction, its intracellular concentration decreases leading to the closure of CNG channel (the closed status is designated as CNG channel) (Dhallan et al. 1992, Chen et al. 1993). Channel closure reduces the inward flux of sodium and calcium (also known as the 'dark current') resulting in cell hyperpolarisation. Cooperative binding of cGMP to the CNG channel confers additional amplification to the phototransduction cascade (Pugh & Lamb 1993, Yau & Baylor 1989).

Literature References

PubMed ID	Title	Journal	Year
8382952	Amplification and kinetics of the activation steps in phototransduction Pugh, EN, Lamb, TD	Biochim. Biophys. Acta	1993
2467600	Cyclic GMP-activated conductance of retinal photoreceptor cells Yau, KW, Baylor, DA	Annu. Rev. Neurosci.	1989
1379636	Human rod photoreceptor cGMP-gated channel: amino acid sequence, gene structure, and functional expression. Reed, RR, Yau, KW, Nathans, J, Macke, JP, Dhallan, RS, Shows, TB	J Neurosci	1992
7682292	A new subunit of the cyclic nucleotide-gated cation channel in retinal rods Peng, YW, Reed, RR, Yau, KW, Dhallan, RS, Ahamed, B, Chen, TY	Nature	1993