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Collagen type XXIII binds Integrin alpha2beta1
Stable Identifier
R-HSA-2473511
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
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Extracellular matrix organization (Homo sapiens)
Integrin cell surface interactions (Homo sapiens)
Collagen type XXIII binds Integrin alpha2beta1 (Homo sapiens)
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Collagen type XXIII, a transmembrane collagen, binds integrin alpha2beta1, the only collagen-binding integrin present in the epidermis, in an ion- and conformation-dependent manner. Binding is sufficient to induce integrin alpha2beta1-dependent attachment and spreading of keratinocytes (Veit et al. 2007, 2011).
Participants
Input
Collagen type XXIII [plasma membrane]
(Homo sapiens)
ITGA2:ITGB1 [plasma membrane]
(Homo sapiens)
Output
Collagen type XXIII:Integrin alpha2beta1 [plasma membrane]
(Homo sapiens)
Participates
as an event of
Integrin cell surface interactions (Homo sapiens)
Inferred From
Collagen type XXIII binds Integrin alpha2beta1 (Homo sapiens)
Authored
Jupe, S (2012-08-08)
Reviewed
Ricard-Blum, S (2013-08-13)
Created
Jupe, S (2012-09-24)
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