Endostatin degradation by cathepsins

Stable Identifier
R-HSA-2471621
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
extracellular region
ReviewStatus
5/5
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Endostatin degradation by cathepsins
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As well as generating endostatin from collagen XVIII, cathepsins L and B quickly degrade it, as do cathepsins D and K. In contrast MMPs that produce endostatin do not cleave it further (Ferreras et al. 2000).
Literature References
PubMed ID Title Journal Year
11119712 Generation and degradation of human endostatin proteins by various proteinases

Ferreras, M, Felbor, U, Lenhard, T, Olsen, BR, Delaissé, J

FEBS Lett. 2000
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Catalyst Activity

serine-type endopeptidase activity of Endostatin-degrading cathepsins [extracellular region]

Physical Entity
Endostatin-degrading cathepsins [extracellular region] (Homo sapiens)
Activity
serine-type endopeptidase activity (GO:0004252)
Orthologous Events
Endostatin degradation by cathepsins (Bos taurus)
Endostatin degradation by cathepsins (Caenorhabditis elegans)
Endostatin degradation by cathepsins (Canis familiaris)
Endostatin degradation by cathepsins (Drosophila melanogaster)
Endostatin degradation by cathepsins (Gallus gallus)
Endostatin degradation by cathepsins (Mus musculus)
Endostatin degradation by cathepsins (Rattus norvegicus)
Endostatin degradation by cathepsins (Sus scrofa)
Endostatin degradation by cathepsins (Xenopus tropicalis)
Authored
Jupe, S  (2011-07-12)
Reviewed
Sorsa, T  (2012-10-08)
Created
Jupe, S  (2012-09-21)
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