The NC1 domains of collagen types VII (Chen et al. 1999) and X (Luckman et al. 2003) interact with integrin alpha2beta1. During endochondrial ossification, collagen type X is deposited in the hypertrophic zone of the growth plate. It interacts directly with chondrocytes via integrin alpha2beta1 (Luckman et al. 2003).
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