Reactome | CDK1 phosphorylates CDCA5 (Sororin) at chromosomal arms

CDK1 phosphorylates CDCA5 (Sororin) at chromosomal arms

Stable Identifier

R-HSA-2468293

Type

Reaction [transition]

Species

Homo sapiens

Compartment

chromosome, cytosol

ReviewStatus

5/5

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CDK1 phosphorylates CDCA5 (Sororin) at chromosomal arms

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Phosphorylation of CDCA5 (Sororin) coincides with dissociation of CDCA5 from chromosomal arms in prometaphase. Several serine and threonine residues in CDCA5 are phosphorylated by CDK1 in prometaphase, but only the three sites that perfectly match the CDK1 consensus phosphorylation sequence are shown here - serines S21 and S75 and threonine T159 (Drier et al. 2011, Zhang et al. 2011).

Literature References

PubMed ID	Title	Journal	Year
21878504	Regulation of sororin by Cdk1-mediated phosphorylation Dreier, MR, Bekier, ME, Taylor, WR	J. Cell. Sci.	2011
21987589	Interaction of Sororin protein with polo-like kinase 1 mediates resolution of chromosomal arm cohesion Pati, D, Mao, Q, Panigrahi, AK, Zhang, N	J. Biol. Chem.	2011