Separation of sister chromatids

Stable Identifier
Reaction [dissociation]
Homo sapiens
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The cleavage of RAD21 subunit of centromeric cohesin by ESPL1 (separin i.e. separase) promotes dissociation of cohesin complexes from centromeric chromatin at the onset of anaphase, allowing for sister chromatid separation and segregation of replicated chromosomes to daughter cells (Waizenegger et al. 2000, Hauf et al. 2001, Waizenegger et al. 2002).

Literature References
PubMed ID Title Journal Year
11081627 Two distinct pathways remove mammalian cohesin from chromosome arms in prophase and from centromeres in anaphase

Waizenegger, IC, Hauf, S, Meinke, A, Peters, JM

Cell 2000
11509732 Cohesin cleavage by separase required for anaphase and cytokinesis in human cells

Hauf, S, Waizenegger, IC, Peters, JM

Science 2001
12194817 Regulation of human separase by securin binding and autocleavage

Waizenegger, I, Giménez-Abián, JF, Wernic, D, Peters, JM

Curr. Biol. 2002
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Orthologous Events
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