Reactome | Separation of sister chromatids

Separation of sister chromatids

Stable Identifier

R-HSA-2467811

Type

Reaction [dissociation]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

Locations in the PathwayBrowser

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Cell Cycle (Homo sapiens)

- Cell Cycle, Mitotic (Homo sapiens)
  - M Phase (Homo sapiens)
    - Mitotic Metaphase and Anaphase (Homo sapiens)
      - Mitotic Anaphase (Homo sapiens)
        
        Separation of Sister Chromatids (Homo sapiens)
        
        Separation of sister chromatids (Homo sapiens)

General

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The cleavage of RAD21 subunit of centromeric cohesin by ESPL1 (separin i.e. separase) promotes dissociation of cohesin complexes from centromeric chromatin at the onset of anaphase, allowing for sister chromatid separation and segregation of replicated chromosomes to daughter cells (Waizenegger et al. 2000, Hauf et al. 2001, Waizenegger et al. 2002).

Literature References

PubMed ID	Title	Journal	Year
11509732	Cohesin cleavage by separase required for anaphase and cytokinesis in human cells Hauf, S, Waizenegger, IC, Peters, JM	Science	2001
11081627	Two distinct pathways remove mammalian cohesin from chromosome arms in prophase and from centromeres in anaphase Waizenegger, IC, Hauf, S, Meinke, A, Peters, JM	Cell	2000
12194817	Regulation of human separase by securin binding and autocleavage Waizenegger, I, Giménez-Abián, JF, Wernic, D, Peters, JM	Curr. Biol.	2002