Reactome | Photons induce isomerisation of 11c-retinyl to at-retinyl

Photons induce isomerisation of 11c-retinyl to at-retinyl

Stable Identifier

R-HSA-2465917

Type

Reaction [transition]

Species

Homo sapiens

Compartment

photoreceptor outer segment membrane, extracellular region

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Photons induce isomerisation of 11c-retinyl to at-retinyl

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Upon photon absorption, 11-cis-retinal (11cRAL) is isomerised to all-trans-retinal (atRAL). The structure of cone opsins which can ultimately activate G-proteins to initiate phototransduction is denoted as R* (Fan et al. 2002). R* is still bound to atRAL at this stage. The isomerisation is a very fast photochemical process (femtoseconds) (Schoenlein et al. 1991) followed by slower events described in the following reaction.

Literature References

PubMed ID	Title	Journal	Year
1925597	The first step in vision: femtosecond isomerization of rhodopsin Peteanu, LA, Shank, CV, Schoenlein, RW, Mathies, RA	Science	1991
12177057	Rhodopsin with 11-cis-locked chromophore is capable of forming an active state photoproduct Fan, G, Sheves, M, Siebert, F, Vogel, R	J. Biol. Chem.	2002