Photons induce isomerisation of 11c-retinyl to at-retinyl

Stable Identifier
R-HSA-2465917
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Upon photon absorption, 11-cis-retinal (11cRAL) is isomerised to all-trans-retinal (atRAL). The structure of cone opsins which can ultimately activate G-proteins to initiate phototransduction is denoted as R* (Fan et al. 2002). R* is still bound to atRAL at this stage. The isomerisation is a very fast photochemical process (femtoseconds) (Schoenlein et al. 1991) followed by slower events described in the following reaction.

Literature References
PubMed ID Title Journal Year
12177057 Rhodopsin with 11-cis-locked chromophore is capable of forming an active state photoproduct

Fan, G, Siebert, F, Sheves, M, Vogel, R

J. Biol. Chem. 2002
1925597 The first step in vision: femtosecond isomerization of rhodopsin

Schoenlein, RW, Peteanu, LA, Mathies, RA, Shank, CV

Science 1991
Participants
Participant Of
Orthologous Events
Authored
Reviewed
Created
Cite Us!