Reactome | COMP binds Integrin alpha5beta1, Integrin alphaVbeta3, CD47

COMP binds Integrin alpha5beta1, Integrin alphaVbeta3, CD47

Stable Identifier

R-HSA-2426259

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

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COMP binds Integrin alpha5beta1, Integrin alphaVbeta3, CD47

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Cartilage oligomeric matrix protein (COMP, thrombospondin-5) is a 524-kDa pentameric glycoprotein expressed primarily in cartilage, tendon, ligament and synovium. In adult cartilage, COMP has been shown to be located primarily in the inter-territorial matrix between chondrocytes (Murphy et al. 1999). The mature protein is pentameric with each monomer linked to its neighbour by a disulphide bond, located at the amino terminus of the protein (Hedbom et al. 1992, Morgelin et al. 1992).

COMP binds integrin alpha5beta1 (Chen et al. 2005), integrin alphaVbeta3 (Neidhart et al.2005) and CD47 (also known as integrin-associated peptide or IAP, Rock et al. 2010) on the cell surface of chondrocytes and fibroblasts.

Literature References

PubMed ID	Title	Journal	Year
15345499	Galectin-3 is induced in rheumatoid arthritis synovial fibroblasts after adhesion to cartilage oligomeric matrix protein Neidhart, M, Zaucke, F, von Knoch, R, Jüngel, A, Michel, BA, Gay, RE, Gay, S	Ann. Rheum. Dis.	2005
20033473	Cartilage oligomeric matrix protein promotes cell attachment via two independent mechanisms involving CD47 and alphaVbeta3 integrin Rock, MJ, Holden, P, Horton, WA, Cohn, DH	Mol. Cell. Biochem.	2010
16051604	Cartilage oligomeric matrix protein/thrombospondin 5 supports chondrocyte attachment through interaction with integrins Chen, FH, Thomas, AO, Hecht, JT, Goldring, MB, Lawler, J	J. Biol. Chem.	2005