Reactome | Latent TGF-beta-3 binds integrins

Latent TGF-beta-3 binds integrins

Stable Identifier

R-HSA-2396029

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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The LAPs of TGF-beta1 and TGF-beta3 contain RGD sequences near the carboxyl termini that are bound by RGD-binding integrins. LAP3 binds alphaVBeta1, 3, 5 and 6 (Ludbrook et al. 2003) and 8 (Kitamura et al. 2011). Binding to integrins alphaVBeta6 and alphaVBeta8 leads to TGF-beta activation.

Literature References

PubMed ID	Title	Journal	Year
21646718	Mouse and human lung fibroblasts regulate dendritic cell trafficking, airway inflammation, and fibrosis through integrin ?v?8-mediated activation of TGF-? Nishimura, SL, Pittet, JF, Somanath, S, Publicover, J, Lou, J, Gauldie, J, Kitamura, H, Cambier, S, Hill, A, Baron, JL, Goodsell, A, Reichardt, L, Minagawa, S, Marks, JD, Barker, T, Wolters, P, Jablons, D, Markovics, J	J. Clin. Invest.	2011
12358597	The integrin alphavbeta3 is a receptor for the latency-associated peptides of transforming growth factors beta1 and beta3 Horgan, CM, Delves, CJ, Ludbrook, SB, Barry, ST	Biochem. J.	2003