Reactome | FDX1 [mitochondrial matrix]

FDX1 [mitochondrial matrix]

Stable Identifier

R-HSA-2395500

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial matrix

Synonyms

Adrenodoxin, mitochondrial, ADX_HUMAN, Ferredoxin 1

Locations in the PathwayBrowser

Expand all

Disease (Homo sapiens)

- Diseases of metabolism (Homo sapiens)
  - Metabolic disorders of biological oxidation enzymes (Homo sapiens)
    - Defective CYP11A1 causes AICSR (Homo sapiens)
      - Defective CYP11A1 does not cleave 20a,22b-DHCHOL (Homo sapiens)
        
        CYP11A1 mutants:FDXR:FDX1,FDX1L (red.) [mitochondrial matrix] (Homo sapiens)
        
        FDX1,FDX2 (reduced) [mitochondrial matrix] (Homo sapiens)
        
        FDX1 (red.) [mitochondrial matrix] (Homo sapiens)
        
        FDX1 [mitochondrial matrix] (Homo sapiens)

External Reference Information

External Reference

UniProt:P10109 FDX1

Gene Names

FDX1, ADX

Chain

transit peptide:1-60, chain:61-184

Reference Genes

BioGPS Gene:2230 FDX1

COSMIC (genes):FDX1 FDX1

CTD Gene:2230 FDX1

dbSNP Gene:2230 FDX1

ENSEMBL:ENSG00000137714 FDX1

ENSEMBL_homo_sapiens_GENE:ENSG00000137714.3 FDX1

HGNC:3638 FDX1

KEGG Gene (Homo sapiens):2230 FDX1

Monarch:2230 FDX1

NCBI Gene:2230 FDX1

OMIM:103260 FDX1

UCSC:P10109 FDX1

Reference Transcript

RefSeq:NM_004109.4 FDX1

Other Identifiers

11724775_at

11758162_s_at

11758335_s_at

16730996

203646_PM_at

203646_at

203647_PM_s_at

203647_s_at

2230

239161_PM_at

239161_at

3348190

3348191

3348192

3348193

3348199

3348203

3348204

3348205

3348206

3348207

3348208

3348209

36893_at

3903445

45831_r_at

7943721

A_23_P357780

A_33_P3343690

GE60507

GO:0003824

GO:0005506

GO:0005739

GO:0005759

GO:0006091

GO:0006629

GO:0006694

GO:0008202

GO:0008203

GO:0009055

GO:0016491

GO:0022900

GO:0042446

GO:0043226

GO:0046872

GO:0051536

GO:0051537

GO:0071320

GO:0140647

GO:1904322

HMNXSV003020877

Hs.27295.0.A1_3p_at

ILMN_2198812

M23668_at

PH_hs_0028687

TC11000988.hg

g13677224_3p_at

g182493_3p_a_at

Participates

as a component of

Inferred To

FDX1 [mitochondrial matrix] (Bos taurus)

FDX1 [mitochondrial matrix] (Canis familiaris)

FDX1 [mitochondrial matrix] (Danio rerio)

FDX1 [mitochondrial matrix] (Drosophila melanogaster)

FDX1 [mitochondrial matrix] (Gallus gallus)

FDX1 [mitochondrial matrix] (Mus musculus)

FDX1 [mitochondrial matrix] (Rattus norvegicus)

FDX1 [mitochondrial matrix] (Sus scrofa)

fdx1 [mitochondrial matrix] (Xenopus tropicalis)

Cross References

RefSeq

NP_004100.1

OpenTargets

ENSG00000137714

HPA

ENSG00000137714-FDX1

GeneCards

P10109

Ensembl

ENSG00000137714, ENST00000260270, ENSP00000260270

PRO

P10109

Pharos - Targets

P10109

Orphanet

25184

HMDB Protein

HMDBP02111

PDB

3N9Y, 3P1M, 3NA1, 7M8I, 3NA0, 3N9Z