Reactome | Interaction of DAP12 and KIR2DS5

Interaction of DAP12 and KIR2DS5

Stable Identifier

R-HSA-2272668

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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Killer cell immunoglobulin-like two-domain short-tail receptor 5 (KIR2DS5) is an activating KIR receptor expressed on natural killer (NK) cells and subpopulations of T lymphocytes (Nowak et al. 2010). KIR2DS5 has two Ig domains of the D1-D2 type, a short cytoplasmic tail and a positive charged transmembrane (TM) portion.
No physiological ligand has yet been identified for KIR2DS5 but it is able to associate with DAP12 and induce both cytotoxicity and cytokine release when KIR2DS5 is cross-linked with monoclonal antibody (Della Chiesa et al. 2008).

Literature References

PubMed ID	Title	Journal	Year
18624290	Evidence that the KIR2DS5 gene codes for a surface receptor triggering natural killer cell function Vitale, M, Falco, M, Moretta, A, Romeo, E, Balsamo, M, Bottino, C, Moretta, L, Augugliaro, R, Della Chiesa, M	Eur. J. Immunol.	2008
20865034	Does the KIR2DS5 gene protect from some human diseases? Jankowska, R, Tchórzewski, H, Malinowski, A, Wilczyński, J, Kurpisz, M, Nowak, I, Wiland, P, Malejczyk, J, Płoski, R, Magott-Procelewska, M, Giebel, S, Kuśnierczyk, P, Gryboś, M, Chlebicki, A, Pawlik, A, Zoń-Giebel, A, Barcz, E, Łuszczek, W, Klinger, M, Passowicz-Muszyńska, E, Wiśniewski, A, Sun, JY, Majorczyk, E, Senitzer, D	PLoS ONE	2010