TRAF6 binds to p-IRAK2

Stable Identifier
R-HSA-2262777
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Neisseria meningitidis serogroup B, Chlamydia trachomatis
Compartment
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IRAK-2 has two TRAF6 binding motifs that are responsible for initiating TRAF6 signaling transduction (Ye H et al 2002). IRAK2 point mutants with mutated TRAF6-binding motifs abrogate NFkB activation and are incapable to stimulate TRAF6 ubiquitination (Keating SE et al 2007).

Literature References
PubMed ID Title Journal Year
8837778 TRAF6 is a signal transducer for interleukin-1

Cao, Z, Xiong, J, Takeuchi, M, Kurama, T, Goeddel, DV

Nature 1996
12138165 Identification of threonine 66 as a functionally critical residue of the

Ross, K, Yang, L, Dower, S, Volpe, F, Guesdon, F

J Biol Chem 2002
18070982 TRAF6 distinctively mediates MyD88- and IRAK-1-induced activation of NF-kappaB

Muroi, M, Tanamoto, K

J Leukoc Biol 2008
12140561 Distinct molecular mechanism for initiating TRAF6 signalling

Ye, H, Arron, JR, Lamothe, B, Cirilli, M, Kobayashi, T, Shevde, NK, Segal, D, Dzivenu, OK, Vologodskaia, M, Yim, M, Du, K, Singh, S, Pike, JW, Darnay, BG, Choi, Y, Wu, H

Nature 2002
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