TRAF6 binds to p-IRAK2

Stable Identifier
R-HSA-2262777
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Chlamydia trachomatis, Neisseria meningitidis serogroup B
Compartment
plasma membrane, cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
TRAF6 binds to p-IRAK2
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
IRAK-2 has two TRAF6 binding motifs that are responsible for initiating TRAF6 signaling transduction (Ye H et al 2002). IRAK2 point mutants with mutated TRAF6-binding motifs abrogate NFkB activation and are incapable to stimulate TRAF6 ubiquitination (Keating SE et al 2007).
Literature References
PubMed ID Title Journal Year
12138165 Identification of threonine 66 as a functionally critical residue of the

Dower, S, Volpe, F, Ross, K, Guesdon, F, Yang, L

J Biol Chem 2002
8837778 TRAF6 is a signal transducer for interleukin-1

Cao, Z, Kurama, T, Xiong, J, Takeuchi, M, Goeddel, DV

Nature 1996
18070982 TRAF6 distinctively mediates MyD88- and IRAK-1-induced activation of NF-kappaB

Muroi, M, Tanamoto, K

J Leukoc Biol 2008
12140561 Distinct molecular mechanism for initiating TRAF6 signalling

Vologodskaia, M, Kobayashi, T, Wu, H, Cirilli, M, Lamothe, B, Arron, JR, Pike, JW, Ye, H, Shevde, NK, Choi, Y, Yim, M, Darnay, BG, Du, K, Dzivenu, OK, Segal, D, Singh, S

Nature 2002
Participants
Input
Output
Participates
as an event of
Authored
Shamovsky, V  (2012-04-20)
Reviewed
Gillespie, ME  (2010-11-30)
Napetschnig, J  (2012-11-16)
Created
Shamovsky, V  (2012-05-21)
Cite Us!